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A blinded randomized trial of the efficacy of the combined chondroitin sulphate and glucosamine as a treatment for experimentally induced osteoarthritis in horses
Valero Fiorin, Eliti; Miluzzi...
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Introduction
Chondroitin sulphate (CS) and glucosamine (GlcN) demonstrated to be beneficial for osteoarthritis (OA) treatment, decreasing inflammation and cartilage degradation. This study aims to evaluate the efficacy of the intra-muscular (IM) injection of the combined CS/GlcN as treatment for experimentally induced OA in horses.
Materials and methods
Fetlock joints of 16 horses were subjected to linear chondral lesions through arthroscopy and these were assigned to treated (TG) or control groups (CG). Eight horses of TG were treated with a total of seven IM injections of CS/GlcN at a 2mL/100kg dose, 5-days intervals. Clinical, laboratorial, and diagnostic imaging examinations were performed before OA-induction, and each 5 days at D6, D11, D16, D21, D26, D31 e D36. Lameness was evaluated subjectively (AAEP scale) and objectively (Lameness Locator®). Joint perimetry, flexion angle, radiographic and ultrasonographic examination were also performed besides measurements of synovial biomarkers CTX- II and PGE2.
Results At D11 (p=0,033) and D21 (p=0,055) there was a significant decrease of lameness grades in TG, as well as reduction of joint circumference at D21 (p=0,009) and D36 (p=0,015). The blinded ultrasonographic evaluation yielded lower scores for the TG at D26 (p=0,038) and concentrations of CTX-II were significantly lower at D31 (p=0,05) when compared to CG.
Conclusion
In such context, the treatment was able to modulate the inflammatory response in TG, providing symptoms reduction and benefits to joint metabolism in triggering surgically induced OA. The association of CS/GlcN, when administered intramuscularly, has the potential to attenuate the signs of experimental OA in horses.
References
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About
Affiliation of the authors at the time of publication
1 University of São Paulo, Department of Surgery, São Paulo, Brasil ; 2 University of São Paulo, Department of São Paulo, São Paulo, Brasil
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