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Use of bisphosphonates in bone disease
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Equine bone is similar to bone in other species. After a period of growing and modelling bone stays in a constant state of remodelling (Fig 1). Physical exercise (increased loading or weightbearing) improves bone mass and influences bone remodelling and modelling. Bone becomes thicker and denser to respond to an increased load. Although the specific mechanisms by which exercise influences it are still not thoroughly understood, local changes are accomplished by the action of bone cells with fast-working osteoclasts resorbing bone and osteoblasts working more slowly to produce new bone. In healthy individuals, the two processes remain in equilibrium, osteoblasts and osteoclasts working evenly together ...
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Affiliation of the authors at the time of publication
University of Lyon, VetAgro Sup - Veterinary Campus of Lyon, Equine Centre, Marcy l’Etoile, France.
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