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Mitomycin C – What Are the Indications and Is There Any Evidence?
F. Malalana
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Mitomycin C (MMC) is an antibiotic isolated from Streptomyces caespitosus. The drug is an alkylating agent with cytotoxic effects on cells including the cross-linking of DNA. Although DNA alkylation can occur at any stage of the cell cycle, the biological consequences are more severe during DNA synthesis. In addition, under aerobic conditions, as occurs predominantly in ophthalmic use, MMC can react with oxygen to generate free radicals, causing cytotoxicity via lipid peroxidation, and DNA and protein damage. In ophthalmic use, MMC has also been shown to inhibit cell migration, extracellular matrix production and fibroblast transformation, giving MMC anti-fibrotic and anti-scarring properties ...
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Affiliation of the authors at the time of publication
Philip Leverhulme Equine Hospital, University of Liverpool, Leahurst Campus, Neston, Wirral, CH64 7TE, UK
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