![Eva Furrow](/sites/default/files/images/media/image/Eva%20Furrow.jpg)
Get access to all handy features included in the IVIS website
- Get unlimited access to books, proceedings and journals.
- Get access to a global catalogue of meetings, on-site and online courses, webinars and educational videos.
- Bookmark your favorite articles in My Library for future reading.
- Save future meetings and courses in My Calendar and My e-Learning.
- Ask authors questions and read what others have to say.
Hypertriglyceridemia-associated proteinuria in Miniature Schnauzers
Get access to all handy features included in the IVIS website
- Get unlimited access to books, proceedings and journals.
- Get access to a global catalogue of meetings, on-site and online courses, webinars and educational videos.
- Bookmark your favorite articles in My Library for future reading.
- Save future meetings and courses in My Calendar and My e-Learning.
- Ask authors questions and read what others have to say.
Read
Proteinuria secondary to primary hypertriglyceridemia is a common yet under-recognized metabolic disorder of Miniature Schnauzers; Eva Furrow describes the diagnostic process and treatment options.
Eva Furrow
VMD, PhD, Dipl. ACVIM - University of Minnesota, College of Veterinary Medicine, St. Paul, MN, USA.
Dr. Furrow qualified from the University of Pennsylvania and after completion of a small animal internship at the same establishment, she moved to the Midwest for a residency in internal medicine followed by a Ph.D. on metabolic and genetic risk factors for urinary stones in dogs, both at the University of Minnesota. She is currently an assistant professor of internal medicine and genetics at the University of Minnesota, where her primary interests include genetic, urinary, endocrine and metabolic disorders.
![Eva Furrow](/sites/default/files/images/media/image/Eva%20Furrow.jpg)
Key Points
- Primary hypertriglyceridemia is common in Miniature Schnauzers and is associated with proteinuria, glomerular lipid thromboemboli, and other glomerular pathology.
- Affected dogs do not typically have azotemia or hypoalbuminemia; if these abnormalities are present, other causes of glomerular disease should be investigated.
- Hyperadrenocorticism is a differential for hypertriglyceridemia and proteinuria and should be ruled out if consistent clinical signs or physical exam abnormalities are present.
- Treatment involves dietary fat restriction and, if necessary, lipid-lowering drugs; proteinuria is managed with drugs that inhibit the renin-angiotensin-aldosterone system.
Introduction
Primary hypertriglyceridemia, also known as familial idiopathic hypertriglyceridemia, is a common yet under-recognized condition in Miniature Schnauzers. This metabolic disorder has an age-dependent manifestation, with a prevalence that increases from 15% of Miniature Schnauzers less than 3 years of age to more than 75% of dogs older than 9 years of age.
Hypertriglyceridemia is typically associated with increased risk for pancreatitis, gallbladder mucoceles, and elevated liver enzymes; more recently, hypertriglyceridemia has also been found to be associated with proteinuria and glomerular pathology in Miniature Schnauzers.
Approximately 50% of Miniature Schnauzers with primary hypertriglyceridemia have proteinuria, and fasting serum triglyceride concentrations have a strong positive correlation with urinary protein-to-creatinine ratios (UPC) in the breed. Furthermore, renal biopsies of proteinuric Miniature Schnauzers with hypertriglyceridemia contain lipid thromboemboli (Figure 1a) (Figure 1b) (Figure 1c) (Figure 1d). These findings suggest that hypertriglyceridemia is the cause rather than the consequence of glomerular disease. This paper presents the features and consequences of hypertriglyceridemia-associated proteinuria in Miniature Schnauzers and provides information on how to diagnose and manage the condition. [...]
Get access to all handy features included in the IVIS website
- Get unlimited access to books, proceedings and journals.
- Get access to a global catalogue of meetings, on-site and online courses, webinars and educational videos.
- Bookmark your favorite articles in My Library for future reading.
- Save future meetings and courses in My Calendar and My e-Learning.
- Ask authors questions and read what others have to say.
About
How to reference this publication (Harvard system)?
Author(s)
Copyright Statement
© All text and images in this publication are copyright protected and cannot be reproduced or copied in any way.Related Content
Readers also viewed these publications
Subscribe
Access to the content of the Veterinary Focus website is reserved for animal health professionals. If you do not yet have a user account with Royal Canin you can create a free account by selecting the New User form. Subscription to the journal is free and issues in your preferred language can be obtained at the Veterinary Focus website.
![Royal Canin](/sites/default/files/images/media/image/hero2_0.png)
Comments (0)
Ask the author
0 comments