![Lesponne I.](/sites/default/files/images/media/image/39.jpg)
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Quality control for hydrolyzed diets
Isabelle Lesponne, Jerôme Naar
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Identifying a suitable diet for pets with adverse food reaction can be less than straightforward and pitfalls await the unwary; here Jérôme Naar and Isabelle Lesponne outline how Royal Canin ensure their Anallergenic diets are free from unwanted proteins.
Isabelle Lesponne
DVM
Dr. Lesponne graduated from the National Veterinary School of Toulouse in 2001 and worked in small animal practice for several years before moving to an animal pharmaceutical company in 2007. She has served as scientific support manager at Royal Canin R&D since 2011.
![Lesponne I.](/sites/default/files/images/media/image/39.jpg)
Jérôme Naar
PhD
Dr. Naar has a background in biochemistry, environmental science and toxicology and joined Royal Canin in 2012 as an expert within the Quality & Food Safety team in R&D. Prior to this, he worked with the Pasteur Institute in French Polynesia before relocating to the USA to manage a research laboratory specializing in environmental toxicology.
![Naar J.](/sites/default/files/images/media/image/40.jpg)
Key Points
- Recent studies have highlighted that the contents of many diets claiming to be suitable for adverse food reactions are potentially not fit for purpose.
- Royal Canin Anallergenic diets are manufactured to exacting standards which ensure they are appropriate for animals that suffer from adverse food reactions.
Adverse Food Reactions (AFR) in dogs and cats are a not-uncommon cause of dermatological signs presented in clinical practice. Commercial AFR diets are often used in both the diagnosis (via an elimination trial) and treatment of the condition, and two broad categories of diets are available:
1. “Selected“ or “novel“ protein diets, with limited protein sources and – ideally – a single carbohydrate source.
2. “Hydrolyzed diets“, consisting of partially or extensively hydrolyzed protein.
Elimination diet trials can be subject to various potential failures. Two major concerns are that the AFR diet must be free of ancillary proteins (as potential cross-contamination in petfood factories is a major concern) and (for hydrolyzed diets) have a guaranteed level of hydrolysis, with no remaining allergenic fragments present. Recent studies have highlighted that some commercial (mostly “over-the-counter”) diets marketed for AFR contain undeclared ingredients and/or large molecular weight proteins; for instance, discrepancies were found between protein analyses and labeling in around 75% of diets tested in recent studies ( 1 ) ( 2 ) ( 3 ). Consequently, to ensure the absence of cross-contaminated products, three key elements are required: fully characterized raw materials, fit-for-purpose industrial equipment and cleaning processes, and optimal analytical controls. [...]
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