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Drugs And Diet In The Management Of Liver Disease
N. Bexfield
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INTRODUCTION
Hepatocytes have a remarkable capacity for regeneration, which means that early diagnosis and treatment have the potential to reverse disease mechanisms and improve liver function. Treatment of acute liver disease is often supportive, but treatment of chronic liver disease should always be tailored to the findings on a liver biopsy whenever possible. In the absence of biopsy diagnosis, the results of clinical pathology and diagnostic imaging can also help to generate a picture of an individual animal’s disease, and allow supportive therapy to be instigated. However, great care should be taken when administering more specific (and potentially harmful) treatments such as steroids or colchicine without a representative liver biopsy.
The aetiology of many liver diseases in dogs and cats, especially chronic diseases, is currently not well understood, so specific treatments are not possible. Non-specific treatment aimed at slowing progression can, however, make a significant difference to the quality of life and probably also the survival time. Treatment aimed at addressing clinical signs of liver disease, including ascites, gastrointestinal ulceration leading to melena and hepatic encephalopathy is also an important part of therapy. Careful dietary management to support the liver is very important too. The aims of treatment of liver disease in dogs and cats are summarised in the box below. ...
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Affiliation of the authors at the time of publication
University of Cambridge Department of Veterinary Medicine
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