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Therapy Aimed at Protecting the Liver: Obsolete or Still Up to Date? Part 2: Therapy Results in Cows with Different Diseases and Liver Damages
Fuerll M., Pevec T. and Ringel...
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Objectives: an analysis in ill slaughtered cows and cows with left side abomasal displacement (lda ) shows that the simple fatty liver is the biggest liver deviation. Highest liver lipid content and bad exit occur specially in cows with stronger inflammatory diseases (retained placenta, endometritis), partly caused by cytokine mediated insulin resis-tance as well as blood coagulation disturbances. the aim of this study were the therapy results in cows with different diseases and liver damages.
Materials and Methods: therapy results were analysed in 4 studies: a) 236 cows with lda and standard therapy (100 mg glucose/h/kg/d in 0,9% nacl; 2x200 g/d propylene glycol, 3 d chemotherapy, antiphlogistics); b) in 40 of 408 selected cows with strong liver damages ( gldH >100 U /l, bilirubin >50 µmol/l, AST >200 U /l) and standard therapy; c) in 50 cows with septicaemia puerperalis, standard therapy and in 25 cows additional dexamethasone; d) blood clotting analysis in 60 cows with sIrs.
Results:
a) From 236 lda cows were 211 cured and 25 died. after standard therapy normalized ketone bodies and bilirubin (p<0.05); gldH, ggt, ldH, A P, and AST remained low. cholesterol, pH-value, bicarbonate (p<0.05) as well as potassium and thrombocytes referred to bad exit.
b) 26 (65%) of 40 cows with strong liver damages were cured unproblematic. ketone bodies, bilirubine and gldH were decreased every time. 35% of died cows had a primary diseases with hopeless prognosis.
c) In cows with septicaemia puerperalis with additional dexamethasone therapy were in contrast to standard therapy heart rate, respiratory rate, rumen movies, bilirubine, FFa , ast, GGT and gldH (p<0.05) improved. Monocytic phagocytosis as well as the oxidative burst of monocytes and granulocytes increased significantly.
d) cows with puerperal disorders had clotting disturbances. Fibrin, factor XIII-, d-dimers, procalcitonin and thrombocytes referred to a bad exit. Heparin (180 Ie /kg bw) can used for treatment resp. prevention of clotting disturbances.
Conclusions: therapy aimed at protecting the liver (glucose, glucoplastic substances) is an important part of complete therapy. glucocorticoids (Voren®), vitamin-B12 ( catosal®), vitamin C / e, menbuton ( genabil®), carnitin, niacin und cis-linolic acid ( CLA ) can be supportive. deciding are a quickly diagnosis of additional diseases and a consequent aetiologically therapy with acting antibiosis, maximal inflammatory inhibition, enzymatic as well as plasmatic antioxidants, circulatory stabilisation, electrolyte substitution as well as inhibition of thrombosis.
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Affiliation of the authors at the time of publication
Large Animal Clinic for Internal Medicine, Section Ruminants, Germany
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