Incomplete List of Teratogens Used in Clinical Medicine

Incomplete List of Teratogens Used in Clinical Medicine

Chemical

Dosage

Acetazolamide

0.6% (in diet)

ACTH

5 mg q 6 h/3 days

Actinomycin D

25 - 100 mcg/kg

Alcohol

1.0 - 210 gm/kg

Aldosterone

0.05 mg/day

Amantadine HCl

10 mg/kg

Aminophylline

100 - 200 mg/kg

Aminopterin

0.1 mg/kg

Anesthetics

-

Antibodies

-

Apomorphine

0.025 mg/embryo (chick)

Barbituric Acid

0.16% (mice) (in diet)

Busulfan

18 - 34 mg/kg

Caffeine

75 - 150 mg/kg

Chlorambucil

8 - 12 mg/kg

Chloramphenicol

100 - 200 mg/kg

Chlortetracycline

10 mg/kg

Colchicine

1 - 2 mg/kg (monkey)

Cortisone

-

Coumarin Derivatives

4 mg/kg (mice)

Dextroamphetamine Sulfate

1 mg/kg

Diazepam

200 mg/kg

Diethylstilbestrol

10 - 42 mg

Dimethyl Sulfoxide

4.0 ml/kg

Diphenylhydantoin

75 - 150 mg/kg (mice)

Disulfiram

100 mg (in diet)

L-Dopa

10 mg/kg

Epinephrine

1 - 50 mcg

Fluorouracil

12 - 37 mg/kg

Griseofulvin

50 - 500 mg/kg

Hypervitaminosis A

35,000 I.U.

Imipramine

15 mg/kg

Isoniazid

-

Lithium

212 mg/kg hen 85 mg/kg

Marihuana

4.2 mg/kg

Meclizine

20 - 80 mg/kg

Methaqualone

0.8% (in diet)

Methotrexate

10 mg/kg (mice)

Nitrous oxide

50% (by inhalation)

Noradrenalin

25 mcg/embryo

Phenobarbital

0.16% (mice) (in diet)

Physostigmine

0.05 - 15.0 mg/embryo (chick)

Pilocarpine

3 - 12 mg/embryo (chick)

Prednisolone

2.5 mg/kg

Prochlorperazine

2.5 - 10 mg/day

Reserpine

1.5 mg/kg

Salicylate

300 mg/kg

Sulphonamides

50 mg/kg

Tetracycline

40 - 80 mg/kg

Tolbutamide

300 mg/day