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Rethinking sperm: lessons from mitochondrial function
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Biological nature of age-related declining fertility in males of any species, including stallions, has been elusive. In horses, economic costs to the breeding industry are frequently considered extensive. Mitochondrial function in ejaculated sperm, essential for sperm motility, is reflected by the dynamic processes of adenosine triphosphate production, mitochondrial oxidative efficiency and production of reactive oxygen species; this balance may become compromised in aging stallions and during cryopreservation process. This presentation will focus on mitochondrial integrity and function as an avenue for understanding the pathophysiology of sperm undergoing cryopreservation and male aging
Sperm, mitochondrial function, oxidative phosphorylation, reactive oxygen species
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Affiliation of the authors at the time of publication
Department of Anatomy, Physiology, and Cell Biology, School of Veterinary Medicine, University of California, Davis, CA, USA.
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