SFT - Theriogenology Annual Conference 2019
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Antisperm antibodies and immune mediated infertility. Are we missing something?

Author(s):
Ferrer M.
In: SFT - Theriogenology Annual Conference - Savannah, 2019 by Society for Theriogenology
Updated:
JUL 24, 2019
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Immune mediated infertility was first reported in stallions in the 1990s. Dysregulation of the tolerogenic testicular environment leads to development of autoimmune orchitis (AO), defined as an autoimmune reaction to germ cell and sperm antigens. AO is characterized by testicular interstitial infiltration with leukocytes, immunoglobulin binding to germ cells in seminiferous tubules, disruption of spermatogenesis, production of antisperm antibodies (ASAs) and infertility. Clinical diagnosis of AO is based on detection of ASAs. Furthermore, ASAs can cause infertility by preventing sperm binding to oviductal cells, undergoing capacitation and binding to the zona pellucida. However, ICSI circumvents these effects and enables pregnancies to be obtained from males with ASAs. Other reported treatments include glucocorticoid treatment for immunosuppression, ...

Autoimmune orchitis, equine, stallion, semen, sperm directed antibodies

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How to reference this publication (Harvard system)?

Ferrer, M. (2020) “Antisperm antibodies and immune mediated infertility. Are we missing something?”, SFT - Theriogenology Annual Conference - Savannah, 2019. Available at: https://www.ivis.org/library/sft/sft-theriogenology-annual-conference-savannah-2019/antisperm-antibodies-and-immune-mediated-infertility-are-we-missing-something (Accessed: 04 June 2023).

Affiliation of the authors at the time of publication

Department of Large Animal Medicine, College of Veterinary Medicine, University of Georgia, Athens, GA, USA.

Author(s)

  • Maria Ferrer

    Ferrer M.

    Associate Professor
    DVM, MS, DACT
    Department of Large Animal Medicine, Veterinary Teaching Hospital,
    Read more about this author

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The Society for Theriogenology is an organization of veterinarians dedicated to animal reproduction, whose mission is to promote standards of excellence in reproductive medicine, to provide outreach and education to veterinarians, and to foster continual improvements in theriogenology.

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