GnRH Immunization for the Treatment of Urinary Incontinence in Spayed Bitches

Introduction Urinary incontinence is common in spayed bitches (4.9-20%). It has been postulated that permanently elevated gonadotropin concentrations as a result of ovariectomy may contribute to the development of this condition. Therefore, the purpose of this study was to determine whether or not a gonadotropin-releasing hormone (GnRH) vaccine, labeled for the management of benign prostatic hyperplasia in intact male dogs, would also be effective for the treatment of urinary incontinence in spayed bitches. It was hypothesized that spayed incontinent bitches immunized against GnRH would develop antibodies that would prevent gonadotropin elevation and permit a return to continence. [...]