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  4. SFT - Theriogenology Annual Conference - Fort Collins, 2017
  5. Cross-Species Comparison of Chromosomal Instability During Mammalian Pre- Implantation Development
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Cross-Species Comparison of Chromosomal Instability During Mammalian Pre- Implantation Development

Author(s):
Metcalf E.S.
In: SFT - Theriogenology Annual Conference - Fort Collins, 2017 by Society for Theriogenology
Updated:
AUG 05, 2017
Languages:
  • EN
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    One of the first major milestones in early mammalian development is blastocyst formation and yet, less than half of pre-implantation embryos from most mammals will reach this stage following in vitro fertilization (IVF). A leading cause of IVF failure and embryo loss in humans is the presence of whole chromosomal imbalances, or aneuploidy. Although more likely to arrest at the cleavage-stage, aneuploid embryos may still form blastocysts and often morphologically indistinguishable from chromosomally normal (euploid) embryos. Chromosomal mis-segregation in oocytes during meiosis is considered the primary reason for aneuploidy in cases of advanced maternal age. However, mosaic aneuploidies, which are mitotically derived, occur just as frequently and irrespective of maternal age. The potential cause(s) of mitotic aneuploidy, whether it can be non-invasively detected, and if preimplantation embryos from other mammalian species are also chromosomally unstable was the focus of this study. Using a combination of time-lapse imaging to monitor embryo development ...

    Aneuploidy, imaging, micronuclei, mitosis, sequencing

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    How to reference this publication (Harvard system)?

    Metcalf, E. (2017) “Cross-Species Comparison of Chromosomal Instability During Mammalian Pre- Implantation Development”, SFT - Theriogenology Annual Conference - Fort Collins, 2017. Available at: https://www.ivis.org/library/sft/sft-theriogenology-annual-conference-fort-collins-2017/cross-species-comparison-of (Accessed: 22 September 2023).

    Affiliation of the authors at the time of publication

    a Department of Cell, Developmental and Cancer Biology; Graduate Program in Molecular and Cellular Biosciences, Oregon Health and Science University, School of Medicine; Portland, OR;
    b Division of Reproductive and Developmental Sciences; Oregon National Primate Research Center , Beaverton, OR;
    c Division of Reproductive Endocrinology and Infertility; d Departments of Obstetrics and Gynecology and Physiology and Pharmacology, Oregon Health and Science University, School of Medicine, Portland, OR

    Author(s)

    • Metcalf E.S.

      MS DVM Dipl ACT
      Honahlee PC,
      Read more about this author

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    Society for Theriogenology

    The Society for Theriogenology is an organization of veterinarians dedicated to animal reproduction, whose mission is to promote standards of excellence in reproductive medicine, to provide outreach and education to veterinarians, and to foster continual improvements in theriogenology.

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