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Concentrations of Sulfadiazine-Trimethoprim in Serum and Endometrium of Mares Treated with an Oral Suspension

Author(s):
Pinto C.R.,
Paccamonti D.L. and
Causey R.C.
In: SFT - Theriogenology Annual Conference - Fort Collins, 2017 by Society for Theriogenology
Updated:
AUG 05, 2017
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We hypothesized that a novel oral suspension of potentiated sulfonamide would reach adequate tissue concentrations greater than the in vitro MIC reported for common uterine pathogens. The objective of our experiment was to assess the concentrations of sulfadiazine-trimethoprim in plasma and the endometrium in non-pregnant mares following treatment with an oral formulation. To test our hypothesis, twenty healthy cycling mares, (ages 3 to 18 y; median 10.5 y) had endometrial biopsies performed and were declared free of endometrial inflammation per histology. In a subsequent estrus, transrectal ultrasonography was performed on the mares to determine the presence of uterine edema and a follicle ≥30 mm in diameter ...

bacterial endometritis, sulfadiazine, trimethoprim, antibiotic tissue penetration, endometrium.

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How to reference this publication (Harvard system)?

Pinto, C. R., Paccamonti, D. and Causey, R. (2017) “Concentrations of Sulfadiazine-Trimethoprim in Serum and Endometrium of Mares Treated with an Oral Suspension”, SFT - Theriogenology Annual Conference - Fort Collins, 2017. Available at: https://www.ivis.org/library/sft/sft-theriogenology-annual-conference-fort-collins-2017/concentrations-of-sulfadiazine (Accessed: 24 September 2023).

Affiliation of the authors at the time of publication

a School of Veterinary Medicine, Louisiana State University, Baton Rouge, LA;
b School of Food and Agriculture (Animal and Veterinary Sciences), University of Maine, Orono, ME

Author(s)

  • Carlos Roberto Pinto

    Pinto C.R.

    Professor
    M.M.V. PhD DACT
    Veterinary Clinical Sciences (VCS), School of Veterinary Medicine, Louisiana State University
    Read more about this author

  • Paccamonti D.L.

    DVM MS
    Department of Veterinary Clinical Sciences, School of Veterinary Medicine, Louisiana State University
    Read more about this author

  • Causey R.C.

    DVM PhD
    Department of Animal and Veterinary Sciences, University of Maine
    Read more about this author

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The Society for Theriogenology is an organization of veterinarians dedicated to animal reproduction, whose mission is to promote standards of excellence in reproductive medicine, to provide outreach and education to veterinarians, and to foster continual improvements in theriogenology.

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