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Treatments for Latent Infections, Bacterial Biofilms, and Fungal Endometritis
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The goal for treating mares with latent or dormant bacteria is to get the bacteria to move from the dormant state into a metabolically active state in which identification and treatment can be performed. Recent work by Petersen et al (2015) has shown that dormant Streptococcus zooepidemicus can be activated by infusing a proprietary medium (bActivate) into the uterus. After the infusion (24 hours) 64% (15/25) mares were culture positive for Streptococcus zooepidemicus as compared to 8% (1/12) mares infused with phosphate buffered saline (PBS). The proprietary medium is capable is able to get bacteria to convert from the dormant state to a metabolically active state and treatment can be initiated. Interestingly, it should be noted that breeding also may result in bacteria being activated from a dormant state. Recent work by Christoffersen et al (2015) showed that 55% (16 of 29) of mares with a negative culture prior to breeding but retained fluid after breeding were positive for growth of ...
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Affiliation of the authors at the time of publication
Equine Reproduction Laboratory, Colorado State University, Fort Collins, CO
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