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Estradiol-17β and Alpha-Fetoprotein as Diagnostic Markers for Ascending Placentitis in a Quarter Horse Broodmare
L. Rothrock, R.E. Ellerbrock and I...
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Placentitis is the leading cause of late-term pregnancy wastage in mares. Diagnosis of placentitis is based on clinical signs (vulvar discharge and premature lactation) and transrectal ultrasonography. While transrectal ultrasonography is a valuable diagnostic tool, early stages of ascending placentitis can be missed. Recently, estradiol-17S and alpha-fetoprotein (products of the fetoplacental unit) were shown to be reduced and elevated, respectively, in plasma of mares with experimentally induced placentitis. It remains to be determined whether these molecules are useful markers for spontaneous placentitis. A 14 year-old mare at approximately 300d gestation was presented to our clinic for premature lactation. [...]
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