Expression of Nectin-4 in Canine Mammary Carcinomas
Author(s):
Dolu, H. and Aydogan, A.
In: Israel Journal of Veterinary Medicine - Vol. 73(3) - Sep. 2018 by Israel Journal of Veterinary Medicine by Waner T.
Updated:
SEP 01, 2018
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In this research, 30 canine mammary tumor tissues which were diagnosed as tubulopapillary carcinoma and complex carcinoma were used. The routine avidin-biotin-peroxidase complex method (ABC) was applied for detection of Nectin-4, Proliferating Cell Nuclear Antigen (PCNA) and Ki-67 in these tissues. The results were analyzed comparatively and evaluated semi-quantitatively. Immunohistochemically, Nectin-4 was expressed in the plasma membrane and cytoplasm of malignant tumor cells. Statistically, positive, linear and a high correlation was observed between Nectin-4, PCNA and Ki-67 expressions. For this reason, it has been concluded that Nectin-4 may be of significant prognostic value relating to malignancy in canine mammary carcinomas.
Canine Mammary Carcinomas; Immunohistochemistry; Nectin-4; PCNA; Ki-67
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Affiliation of the authors at the time of publication
University of Mehmet Akif Ersoy, Faculty of Veterinary Medicine, Department of Pathology, 15030 Burdur, Turkey. University of Çukurova, Faculty of Ceyhan Veterinary Medicine, Department of Pathology, 01930, Adana, Turkey.
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