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Clinical Evaluation of Deslorelin to Induce Oestrus, Ovulation and Pregnancy in the Bitch
A. von Heimendahl and C. Miller
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INTRODUCTION: The long intervals between and the inability to induce oestrus are a specific problem of dog breeding. More recently Deslorelin has been used to overcome this. One of the problems has been that although the implant reliably induces oestrus, ovulation does not always occur. In this study the implants were left in until ovulation had occurred or blood progesterone regressed to basic levels despite the presence of Deslorelin.
OBJECTIVES AND METHODS: Deslorelin is a GnRH agonist that has been shown to reliably induce oestrus (1) and also ovulation (2). Pregnancy rates following Deslorelin implants have varied between studies (3) (4). The aim of this study is to evaluate the removal of Deslorelin after ovulation and assess pregnancy rates. The study used 16 late anoestrus bitches (at least 160 days since previous oestrus) that had come to the clinic for various reasons such as long anoestrus period (more than 10 months), timing of mating and whelping for convenience of the owner and previous unsuccessful seasons. The bitches were of different breeds, ages and reproductive history. Deslorelin (Suprelorin®4.7mg, Virbac) was implanted on Day 0 subcutaneously in the ventral abdomen close to the umbilicus. Onset of oestrus was noted. Time of ovulation was determined by serum progesterone levels and ovulation itself was defined as progesterone concentration greater than 15nmol/l. Blood samples for progesterone levels were not taken every day as have been described in previous studies (2) due to the clinical nature of the trial. The Deslorelin implant was removed as soon as ovulation had been detected under local anaesthesia. The clinician had limited influence on breeding regime and bitches were mated one to four days after ovulation to unknown dogs according to owner’s will. [...]
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