Keratinocyte Stem Cell Expression is Supported by Epidermal-dermal Cell Interactions in the Bovine Sensitive Lamina in Vitro

A greater understanding of factors orchestrating keratinocyte growth, differentiation and maturation in hoof horn production are pivotal to understanding hoof horn properties in health and disease. Chemical signaling between keratinocytes and fibroblast play an important role in normal keratinocyte biology by directing proliferation, differentiation, and cellular apoptosis. However, changes in tissue keratinocyte-fibroblast interaction can alter cell-cell communication and impact architecture, intercellular adherence, stem cell proliferation, cell differentiation, keratin expression, and keratinocyte apoptosis (Smola, 1993). Defining events orchestrating keratinocyte growth and development during health and disease would lead to a better understanding of the biology of normal and abnormal hoof horn formation in the bovine claw ...