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Clinical Trial on the Curative Effect of Intra Hoof-Fit Gel on Digital Dermatitis
M. Holzauer
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Digital dermatitis (DD) is an increasing problem in modern dairy industry. Intra HoofFit gel© (IHF, Intracare) is a water-based gel with active components copper and zinc for topical treatment. A trial was conducted from in 2009-2010 on 5 commercial dairy herds, to estimate the efficiency of IHF as a treatment for ulcerative DD lesions (M2) in comparison with a registered antibiotic spray (CTC-spray©, Eurovet). All the farms included had slatted floors with cubicles and cows included in the trial were in different stages of lactation. Cows with M2 lesions were divided into two groups and randomly treated either with IHF or treated with CTC and claws were inspected on d7, d21 and d28. The experimental unit was the hind leg with an ulcerative DD lesion (M2) and cure was defined as the transition of an M2 into a non-ulcerative stage at D28. A two-sample proportion test was used to test the efficiency of IHF compared with CTC. The principal objective for this efficiency testing was to show the non inferiority of the cure rate of IHF to the cure rate of CTC. Results Overall, the cure rate for M2 over 28 days was 0.92 for IHF compared with 0.58 for CTC. Thus, the risk difference equalled 0.92 - 0.58 = 0.34 (95% CI: 0.22 - 0.45). So the cure rate of Intra Hoof-Fit gel© was significantly better than CTC-spray©. At individual herd level, the cure rate of IHF was statistically significant higher than CTC in 3 out of 5 herds.
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