Cytopathological Diagnosis of the Canine Hepatoid Gland Tumors

Introduction
A hepatoid (perianal) gland tumor is a type of tumor found near the anus in dogs that arises from specialized glandular tissue (1,2). it is also known as a hepatoid tumor because of the similarity in cell shape to hepatocytes (liver cells) (1,2,3). in this study, 23 tumors of dogs were evaluated and compered between cytopathologically and his- topathologically.

Material and Methods
23 tumors of dogs were evaluated and compered between cytopathological and cis- topathological. for cytopathology examination fnaB technique were performed and slides were stained with May-Grünwald Giemsa. for histopathological examination tis- sue samples were fixed formaldehyde solution, after processed by paraffin technique sections were stained by Hematoxylin-Eosin.

Results
Total 23 tumors were diagnosed by cytology and confirmed by histology. Macroscopi- cally, the masses covered with hairless skin and often ulcerated. Cut sections were pale brown and multilobulated. Cytopathologically, large and cuboidal epithelial cells have low nuclear/cytoplasm ratios. nucleus were round to ovoid, pleomorphism were mild. also, abundant, granular bluish cytoplasm were seen. the distinctive histopathologic feature of this tumor is differentiation to large hepatocyte-like cells, which have an abundant eosinophilic cytoplasm. Within the tumor cells trabeculae and islands subdi- vided by a well vascularized stroma.

Conclusions
Cytopathological examination is a quick and easy procedure to perform which needs minimum of especial equipments and requires little training. it can be considered, in experienced hands and is reliable for the confirmation and differentiation of canine hepatoid gland tumors.