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Klassifizierung und Ätiologie
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Chronische Niereninsuffizienz (CNI) ist die Folge des fortschreitenden und irreversiblen Verlustes an funktionellen Nephronen, an deren Stelle funktionsloses Narbengewebe und entzündliches Infiltrat tre- ten. Die Ätiologie der CNI ist multifaktoriell: Neben der angeborenen chronischen Niereninsuffizienz unterscheidet man die sekundäre CNI, die nach all jenen erworbenen Erkrankungen entsteht, die eine Schädigung der Glomerula und Tubuli sowie von Interstitium und Gefäßen verursachen (Tabelle 1). Jede Läsion bewirkt letztendlich die Zerstörung des Nephrons, an dessen Stelle nicht-funktionelles fibrö- ses Narbengewebe zurückbleibt (Abbildung 2). […]
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Affiliation of the authors at the time of publication
1Royal Canin USA, MO, USA. 2Experimental Physiopathology and Toxicology, National Veterinary School of Toulouse, Toulouse, France.
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