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Épidémiologie
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Causes
> Affections hépatiques inflammatoires non infectieuses
Elles figurent parmi les hépatopathies les plus fréquentes chez le chien (Tableau 3) (Center, 1996a; Watson, 2004). Le foie possède un système réticulo-endothélial très actif : il joue un rôle barrière impor- tant vis-à-vis des substances provenant du tube digestif et véhiculées par la veine porte, surtout lorsque la muqueuse intestinale est lésée. Le foie est également exposé à des toxines endogènes et exogènes ainsi qu’aux médicaments. Des mécanismes à médiation immunitaire peuvent perpétuer l’inflamma- tion après une lésion hépatique quelle qu’en soit la cause (Center, 1999b). L’hépatite primaire d’origine auto-immune, importante chez l’homme, n’a cependant pas été décrite chez le chien. […]
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Affiliation of the authors at the time of publication
1Departement of Veterinary Clinical Sciences, The Royal Veterinary College, United Kingdom.2Royal Canin Research Center, France.
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