Update on the use of PRP

The Platelet Rich Plasma (PRP) is easy to applicate and has relatively low cost. Its biocompatible and biodegradable properties prevent it from inducing immunological rejection, tissue necrosis or fibrosis. There is no risk of pathogen transmission. The growth factors (GF) contained within the platelets in appropriate proportion are of significance for tissue healing. PRP supplies also cytokines, chemokines, and other bioactive compounds.

What evidence is there of efficacy of PRP ?

Osteoarthrosis (OA)

PRP elicits a mild and self-limiting inflammatory response shortly after intra articular administration without long-term deleterious effects on joint homeostasis.

A single intra-articular injection of PRP result in significant improvement at 12w in dogs with OA involving a single joint (Fahie JAVMA 2013). Dogs with CCL rupture treated with PRP had improved PVF, VI, ST and range of motion over time (Silva VCOT 2013, Vilar PLOs 2018). For dogs underwent partial CCL transection and meniscal release in one knee and assessed over 6 months, saline-treated dogs had significantly more confortable range of motion loss, significantly more pain, significantly more severe lameness, significantly lower function compared to ACP-treated dogs (Cook J Orthop Res 2016). [...]