Skip to main content
menu sluit menu
Home Home
Login
Main navigation
  • Library
  • Calendar
  • e-Learning
  • News
    • Veterinary News In this section you find veterinary news
    • Recent Additions All content that was recently added to the IVIS library
  • Get involved
    • Donate Support IVIS, make a donation today
    • Media kit Promote your e-learning & events on IVIS
    • Add your e-learning & events to the IVIS calendar
    • Publish on IVIS Publish your work with us
  • About
    • Mission Our Mission Statement
    • What we do More info about IVIS and what we do
    • Who we are More info about the IVIS team
    • Authors See list of all IVIS authors and editors
  • Contact
User tools menu
User tools menu
Main navigation
  • Library
  • Calendar
  • e-Learning
  • News
    • Veterinary News In this section you find veterinary news
    • Recent Additions All content that was recently added to the IVIS library
  • Get involved
    • Donate Support IVIS, make a donation today
    • Media kit Promote your e-learning & events on IVIS
    • Add your e-learning & events to the IVIS calendar
    • Publish on IVIS Publish your work with us
  • About
    • Mission Our Mission Statement
    • What we do More info about IVIS and what we do
    • Who we are More info about the IVIS team
    • Authors See list of all IVIS authors and editors
  • Contact
Follow IVIS
  • Twitter
  • Facebook
Support IVIS

Breadcrumb

  1. Home
  2. Library
  3. Concise Review of Veterinary Virology
  4. Circoviridae
Concise Review of Veterinary Virology - Carter G.R.
Back to Table of Contents
Add to My Library
Close
Would you like to add this to your library?

Get access to all handy features included in the IVIS website

  • Get unlimited access to books, proceedings and journals.
  • Get access to a global catalogue of meetings, on-site and online courses, webinars and educational videos.
  • Bookmark your favorite articles in My Library for future reading.
  • Save future meetings and courses in My Calendar and My e-Learning.
  • Ask authors questions and read what others have to say.
Sign in Register
Comments
Print this article
Share:
  • Facebook
  • LinkedIn
  • Mail
  • Twitter

Circoviridae

Author(s):
Carter G.R. and
Wise D.J.
In: Concise Review of Veterinary Virology by Carter G.R. et al.
Updated:
SEP 05, 2006
Languages:
  • EN
  • ES
  • PT
Back to Table of Contents
Add to My Library
Close
Would you like to add this to your library?

Get access to all handy features included in the IVIS website

  • Get unlimited access to books, proceedings and journals.
  • Get access to a global catalogue of meetings, on-site and online courses, webinars and educational videos.
  • Bookmark your favorite articles in My Library for future reading.
  • Save future meetings and courses in My Calendar and My e-Learning.
  • Ask authors questions and read what others have to say.
Sign in Register
Print this article
SHARE:
  • Facebook
  • LinkedIn
  • Mail
  • Twitter
    Read

    Table of Contents

    • Viral Characteristics
      Classification
      Circovirus
              
      Porcine Multisystemic Wasting Syndrome
              Psittacine Beak and Feather Disease
      Gyrovirus
              
      Chicken Anemia
      Glossary

    This is a newly established family of very small, non-enveloped DNA viruses that contains three virus species of veterinary significance.

    Viral Characteristics

    • Very small (17 - 22 nm in diameter), naked icosahedral viruses with a circular, single-stranded DNA genome. The genome encodes a single capsid protein. See illustration of capsid, Fig. 8-1.
    • Replication takes place in the nucleus of dividing cells and is similar to the parvoviruses.
    • The single-stranded circular DNA of circoviruses is thought to be replicated by a rolling circle mechanism.
    • In the cell nucleus, the ssDNA (either negative sense or ambisense) is used as a template for the formation of dsDNA by host repair enzymes. The dsDNA is then used as a template for both mRNA production (for translation of proteins) and copies of the genome for progeny virions. These products are self-assembled into complete progeny virions.
    • Circoviruses are very stable in the environment; resistant to some disinfectants, including detergents.


    Figure 8-1. Illustration of the capsid of a circovirus (17 - 22 nm). From The ViralZone in the ExPASy Bioinformatics Resource Portal.

    Classification

    The family has two genera based on genetic studies. Gyrovirus also differs from Circovirus in the replication cycle and the virions being larger. They are with their species as follows:
    Circovirus:
            
    porcine circovirus type 1
            porcine
    circovirus type 2
            beak and feather disease virus
    Gyrovirus:
            
    chicken anemia virus

    Circovirus

    As mentioned above, there are two porcine circoviruses:
    Porcine circovirus 1 (PCV 1) occurs widely in swine in Europe and North America; it produces non-clinical infections.
    Porcine circovirus 2 (PCV 2) is the cause of postweaning multisystemic wasting disease (PMWS), which is discussed below.
    There is about 80% nucleotide homology between PCV 1 and PCV 2.
    Porcine
    circovirus 2 is antigenically distinct from PCV 1.

    Porcine Multisystemic Wasting Syndrome (PMWS)

    Cause

    Porcine circovirus 2 (PCV 2). The current view is that porcine circovirus 2 (PCV 2) is necessary but not sufficient in itself to cause PMWS. As mentioned below other factors contribute to clinical disease.

    Occurrence

    Porcine multisystemic wasting syndrome is a worldwide, frequently occurring disease of pigs about six weeks of age. The disease occurs as a result of various stresses or concurrent infection with other agents, including porcine parvovirus or porcine reproductive and respiratory syndrome virus.

    Transmission

    It spreads horizontally and transplacental infections occur that may lead to abortion, weak neonates and mummified fetuses.

    Pathogenesis

    After initial infection there is viremia with spread to several organ systems, where lesions are produced.

    Clinical & Pathologic Features

    Weight loss, poor body condition, rough coat, diarrhea, debility, jaundice, lymphadenopathy (both T and B lymphocytes) and dysnea are characteristic.
    There is granulomatous inflammation in several organ systems, which may include lung, kidney, liver, lymph nodes, spleen, tonsil, thymus and Peyer’s patches. Large multiple basophilic intracytoplasmic inclusion bodies are frequently seen in macrophages and multinucleated giant cells.
    The mortality rate may reach 10% in outbreaks.

    Diagnosis

    • Clinical specimens: preferably a whole pig; lungs, liver and kidney.
    • A tentative diagnosis is based on age susceptibility, clinical signs and lesions.
    • Definitive diagnosis is accomplished by fluorescent antibody staining of the virus in infected tissues.
    • Immunofluorescence assay and ELISA are used to detect antibodies although the presence of specific antibody alone is not diagnostic.
    • Although the virus can be cultivated in cells, virus isolation is not usually feasible for diagnostic laboratories. Many swine cells used for virus isolation are contaminated with PCV, which may lead to misdiagnosis.

    Prevention

    • Aqueous sodium chlorite solution is effective for the disinfection of premises. The virus is resistant to detergents.
    • Removal of affected animals.
    • An inactivated circovirus type 2 vaccine is available to aid in the prevention of PMWS. It is administered to piglets four weeks of age and older.

    Psittacine Beak and Feather Disease

    Cause

    Beak and feather disease virus (Circoviridae).

    Occurrence

    Psittacine beak and feather disease (PBFD) affects many species of psittacine birds worldwide. Cockatoos are particularly susceptible.

    Transmission

    Virus spread is by direct and indirect contact. Infection occurs mainly by the alimentary and respiratory routes.

    Clinical & Pathologic Features

    The disease is seen in both chronic and acute fatal forms. The virus specifically infects the cells of the immune system and those cells that produce feathers and beak.

    The cardinal signs of the chronic disease involve the beak and feathers. The beak deformities are characterized by palatine necrosis and elongated and easily fractured beaks. Abnormal feathering is progressive, becoming more evident with each molt, and usually occurs in a symmetrical fashion with normal feathers being replaced by dystrophic feathers that cease to grow shortly after emerging from the follicle.

    The immune system is suppressed and secondary bacterial infections are common.

    An acute form of PBFD occurs in which beak and feather lesions may not be evident. This form is seen most often in young birds and is characterized clinically by lethargy, anorexia, and diarrhea. Affected birds often die.

    Diagnosis

    • Clinical specimens: whole birds and infected feathers.
    • Diagnosis is usually based on clinical signs and histopathologic examination of affected tissues.
    • Intranuclear and intracytoplasmic inclusion bodies are commonly found in feathers, beak, and Bursa of Fabricius.
    • Commercial tests utilizing PCR detect PBFD viral nucleic acid in diseased and asymptomatic birds. This is the best method available for detecting the presence of PBFD virus in the bird's blood when beak or feather lesions are not apparent.
    • The virus has not been successfully propagated in embryonated eggs or cell cultures.

    Prevention

    • No vaccines are currently available.
    • Prevention is best accomplished by good management practices. Note that virus particles can remain viable in the environment for months, long after the infected bird is gone.
    • New additions to aviaries should only be purchased from reliable sources.
    • It is advisable to quarantine and test birds for PBFD virus before introducing them to other psittacine birds.

    Gyrovirus

    Chicken Anemia Virus Infection

    Cause

    Chicken anemia virus (Gyrovirus).

    Occurrence

    A worldwide, common infection of chickens, particularly of commercial flocks and broilers. The virus may infect chickens of all ages.

    Infections are most serious when there is concurrent infection with the infectious bursal disease virus, avian adenovirus, or reticuloendotheliosis virus.

    Transmission

    Direct and indirect spread by the oral-fecal and respiratory routes; also, vertically via the egg and via the semen of infected roosters. Laying hens thus infected are viremic for a period of 1 - 3 weeks. Chicks hatched from infected eggs are viremic and thus a source of infection.

    Pathogenesis

    The viremia developing in infected day-old chicks leads to infection of many organs and specifically T cells in the thymic cortex and bursa, and hemocytoblasts in the bone marrow.

    Clinical & Pathologic Features

    Overt disease is seen only in young chicks within the first 2 - 3 weeks of life. The virus is present in many organs and feces.
    There follows immunosuppression and
    aplastic anemia with atrophy of lymphoid tissue.
    Clinical signs begin at about two weeks of age and include anemia (pale), diarrhea, anorexia, depression and weight loss.
    The mortality rate is usually about 10% but may be as high as 50% if there is dual infection.

    Maternal antibodies prevent the development of clinical disease in chicks.
    Necropsy lesions often noted are subcutaneous and muscle hemorrhages, pale visceral organs, an abnormal fatty-appearing bone marrow and thymic atrophy. Consistent microscopic lesions are found in the bone marrow where erythrocytes and other cells are replaced by fat cells and in the thymus, which is depleted of lymphocytes.

    Diagnosis

    • Clinical specimens: whole chicken, serum.
    • Clinical signs, lesions and the aplastic anemia suggest chicken anemia virus infection.
    • The virus can be cultivated in cells but isolation is not usually diagnostically feasible.
    • Definitive diagnosis depends on the detection of viral DNA in the thymus or bursa by PCR, dot-blot hybridization or in situ hybridization.
    • Serum antibodies can be detected by conventional procedures, such as ELISA.
    • ELISA kits are available and are used to identify and eliminate positive hens before laying.

    Prevention

    • It is difficult to maintain laying flocks free of infection.
    • A procedure used, is to deliberately expose layers before laying begins to infected tissue homogenates or litter from positive flocks.
    • Losses are lessened if flocks are kept free of other immunosuppressive viruses.
    • Antibiotics may be used to control secondary bacterial infections.
    • Live vaccines are administered by injection or in drinking water to antibody-negative breeder flocks prior to the start of egg production.

    Glossary

    Aplastic anemia: An anemia in which the bone marrow fails to produce sufficient numbers of blood elements.
    Dot-blot hybridization: A diagnostic procedure in which the material to be examined is blotted directly on to a membrane (frequently nitrocellulose) then hybridized with reference probes prepared from virus-specific DNA. The probes are labeled (chemically or radioactively) and a signal is detected where hybridization occurs.
    Dystrophic: Maldevelopment caused by or related to faulty nutrition.

    Back to Table of Contents
    Add to My Library
    Close
    Would you like to add this to your library?

    Get access to all handy features included in the IVIS website

    • Get unlimited access to books, proceedings and journals.
    • Get access to a global catalogue of meetings, on-site and online courses, webinars and educational videos.
    • Bookmark your favorite articles in My Library for future reading.
    • Save future meetings and courses in My Calendar and My e-Learning.
    • Ask authors questions and read what others have to say.
    Sign in Register
    Print this article
    Comments (0)

    Ask the author

    0 comments
    Submit
    Close
    Would to like to further discuss this item?

    Get access to all handy features included in the IVIS website

    • Get unlimited access to books, proceedings and journals.
    • Get access to a global catalogue of meetings, on-site and online courses, webinars and educational videos.
    • Bookmark your favorite articles in My Library for future reading.
    • Save future meetings and courses in My Calendar and My e-Learning.
    • Ask authors questions and read what others have to say.
    Sign in Register
    About

    How to reference this publication (Harvard system)?

    Carter, G. R. and Wise, D. J. (2005) “Circoviridae”, Concise Review of Veterinary Virology. Available at: https://www.ivis.org/library/concise-review-of-veterinary-virology/circoviridae-1 (Accessed: 20 March 2023).

    Affiliation of the authors at the time of publication

    1Virginia-Maryland Regional College of Veterinary Medicine, Virginia Tech, Blacksburg, Virginia, USA.2Department of Biology, Concord University, Athens, West Virginia, USA.

    Author(s)

    • Carter G.R.

      Professor Emeritus
      DVM MS DVSc
      Department of Biomedical Sciences and Pathobiology, Virginia-Maryland Regional College of Vet Medicine, Virginia Polytechnic Institute & State University
      Read more about this author
    • Darla Wise

      Wise D.J.

      Associate Professor
      MS PhD
      Department of Biology, Concord University
      Read more about this author

    Copyright Statement

    © All text and images in this publication are copyright protected and cannot be reproduced or copied in any way.
    Related Content

    Readers also viewed these publications

    • Journal Issue

      Veterinary Evidence - Vol 7 N°3, Jul-Sep 2022

      In: Veterinary Evidence
      OCT 04, 2022
    • Journal Issue

      Veterinary Practice Management Articles - Veterinary Focus

      In: Veterinary Focus
      AUG 05, 2022
    • Journal Issue

      Canine and Feline Nutrition - Veterinary Focus - Vol. 24(3) - Nov. 2014

      In: Veterinary Focus
      MAR 04, 2021
    • Journal Issue

      Canine Health and Welfare - Veterinary Focus - Vol. 30(3), December 2020

      In: Veterinary Focus
      JAN 15, 2021
    • Journal Issue

      COVID-19, Special Practice Management - Veterinary Focus - May 2020

      In: Veterinary Focus
      MAY 28, 2020
    • Journal Issue

      The C-Factor: Vet Skills in Communication - Veterinary Focus - Mar. 2020

      In: Veterinary Focus
      MAY 01, 2020
    • Proceeding

      AAVPT - Biennial Symposium - Overland Park, 2019

      By: American Academy of Veterinary Pharmacology & Therapeutics
      AUG 23, 2019
    • Journal Issue

      Kittens and Young Cats - Veterinary Focus - Vol. 29(1), Mar. 2019

      In: Veterinary Focus
      MAR 01, 2019
    • Journal Issue

      Enfermedades emergentes en porcino - Albéitar - N°222, Ene-Feb. 2019

      In: Albéitar
      FEB 01, 2019
    • Journal Issue

      Improving the pet owner experience in your practice - Veterinary Focus - Special Issue

      In: Veterinary Focus
      APR 01, 2018
    • Chapter

      Flaviviridae

      In: Concise Review of Veterinary Virology
      DEC 19, 2008
    • Chapter

      Understanding Cryogenic Liquid Nitrogen Tanks

      In: Reviews in Veterinary Medicine
      MAY 14, 2007
    • Chapter

      Arteriviridae

      In: Concise Review of Veterinary Virology
      SEP 08, 2006
    • Chapter

      Occupational Health in Animal Care, Use and Research

      In: Laboratory Animal Medicine and Management
      JUL 26, 2006
    • Chapter

      Orthomyxoviridae

      In: Concise Review of Veterinary Virology
      MAY 09, 2006
    • Chapter

      Herpesviridae

      In: Concise Review of Veterinary Virology
      MAY 09, 2006
    • Chapter

      Prevention of Viral Diseases, Vaccines and Antiviral Drugs

      In: Concise Review of Veterinary Virology
      MAR 01, 2006
    • Chapter

      Prions and Transmissible Spongiform Encephalopathies

      In: Concise Review of Veterinary Virology
      DEC 14, 2005
    • Chapter

      Cumulative Glossary

      In: Concise Review of Veterinary Virology
      DEC 14, 2005
    • Chapter

      Coronaviridae

      In: Concise Review of Veterinary Virology
      DEC 14, 2005
    • Chapter

      Index of Diseases

      In: Concise Review of Veterinary Virology
      DEC 14, 2005
    • Chapter

      Togaviridae

      In: Concise Review of Veterinary Virology
      DEC 14, 2005
    • Chapter

      Families with Viruses of Minor Veterinary Significance

      In: Concise Review of Veterinary Virology
      DEC 14, 2005
    • Chapter

      Picornaviridae

      In: Concise Review of Veterinary Virology
      NOV 21, 2005
    • Chapter

      Caliciviridae

      In: Concise Review of Veterinary Virology
      NOV 21, 2005
    • Load more
    Back To Top
    Become a member of IVIS and get access to all our resources
    Create an account
    Sign in
    Leading the way in providing veterinary information
    About IVIS
    • Mission
    • What we do
    • Who we are
    Need help?
    • Contact
    Follow IVIS
    • Twitter
    • Facebook
    International Veterinary Information Service (IVIS) is a not-for-profit organization established to provide information to veterinarians, veterinary students, technicians and animal health professionals worldwide using Internet technology.
    Support IVIS
    © 2023 International Veterinary Information Service
    • Disclaimer
    • Privacy Policy