British Equine Veterinary Association
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Medical Management of Corneal Ulcers

Author(s):

A. Matthews

In: BEVA - Annual Congress - Manchester, 2013 by British Equine Veterinary Association
Updated:
SEP 14, 2013
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Most deeper ulcers probably begin as minor superficial trauma. However, some microorganisms, predominantly Gram-positives e.g. Staphylococcus aureus, have been shown capable of acting as primary epithelial pathogens in susceptible individuals.

The host polymorphonuclear neutrophil (PMN) response is the major cause of stromal breakdown!

  • Uncontrolled expression of PMN derived proteolytic enzymes is primarily responsible for progressive corneal breakdown. This is an integral part of the innate local immune response to corneal insult.

  • Ulceration can continue in the absence of microbial infection. PROGRESSING ULCERS CAN BE STERILE!

  • Ocular surface proteinases are normally inhibited by innate inhibitory molecules present in the tear film and cornea. Ulcer progression appears to arise where destructive proteolysis overwhelms the inhibitory capacity present on the ocular surface.

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