British Equine Veterinary Association
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Equine Mesenchymal Stromal Cells Derived from Different Sources: Basic Characteristics and Tendon Marker Expression

Author(s):

Burk J., Ribitsch I., Gittel C...

In: BEVA - Annual Congress - Manchester, 2013 by British Equine Veterinary Association
Updated:
SEP 14, 2013
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Aims: The application of multipotent mesenchymal stromal cells (MSC) for treatment of tendinopathy has become popular in equine clinical practice. While the clinical results of the treatment with bone marrow or adipose-derived MSC are promising, MSC derived from other tissue sources might have even superior properties and tendon regeneration potential. Therefore, the aim of this study was to compare equine MSC derived from different tissues regarding their basic characteristics and tendon marker expression. 

Methods: Equine MSC were isolated from bone marrow, adipose tissue, tendon tissue, and umbilical cord blood and tissue. Subsequent to MSC isolation and the assessment of their proliferation and trilineage differentiation potential, their expression of tendon markers was assessed on mRNA level by real-time RT-PCR. [...]

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