A Prospective Clinical Evaluation of the Comparative Efficacy of Three Trypanocides in the Treatment of Equine Trypanosomiasis in the Gambia: Part 1 Clinical Response and Adverse Effects of Treatments

Aims: 1) To establish relative efficacy of Berenil®, Cymelarsan®and Samorin® in clinical cases of equine trypanosomiasis with respect to improvement in demeanour and packed cell volume (PCV) over a 2-week period following treatment. 2) To document immediate and subsequent adverse reactions relating to the administration of the drugs. 

Methods: Owners were invited to present their horses and donkeys for a free health check or examination to address pre-existing concerns in 5 villages in the up river region of The Gambia. A history was taken from the owner including previous treatment for trypanosomiasis, presenting concerns and history of abortion or inability to conceive. The findings of clinical examination including demeanour, body condition score, PCV and total serum protein were recorded. [...]