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Practical Chondroprotective Drug Use
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When confronted with a horse suffering from acute or chronic joint disease, your therapeutic goals should be aimed at both the soft tissue supportive structures and cartilage within the joint. The joint should not be thought of as simply articular cartilage, but rather as an organ consisting of cartilage, joint capsule, ligaments, synovial fluid and subchondral bone. Your therapeutic goals may be to decrease inflammation, alleviate pain or restore the articular environment to slow progression of disease. Your recommended therapy will likely include a combination of supportive care methods, as well as administration of pharmaceuticals and nutriceuticals.
Hyaluronan
Hyaluronan (HA) is present within articular cartilage where it is synthesised by chondrocytes and in synovial fluid where it is synthesised by type B synoviocytes. Hyaluronan can exist as hyaluronic acid, sodium hyaluronate or as hyaluronate depending on the environment in which it is found, and all terms are used interchangeably. It has been recognised for many years and in several species that in osteoarthritis (OA) the molecular weight and concentration of HA were diminished by one-half to one- third of their normal values, giving rise to the concept of visco- supplementation. [...]
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