Use of cellular therapies in reproductive problems of mares

Most reproductive problems in mares are related to old age, with uterine fibrosis and persistent post-breeding inflammation considered to be the main causes of subfertility in these animals [1]. Currently, the therapies that are used in these animals are supportive, rather than acting directly on the pathological process. Cellular therapies have been used in human and veterinary regenerative medicine. Some studies have already demonstrated the establishment of stem cells in the endometrium [2] and the anti-inflammatory effect when stem cells were infused into the uterus [3]. Also, platelet-rich plasma (PRP) that contains growth factors and interleukins with anti-inflammatory effects has been shown to be effective in the downregulation of endometrial inflammatory markers in mares [4]. Thus, several experiments using cell therapy were developed in ...