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Diagnosing PPID: art or science?
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Pituitary pars intermedia dysfunction (PPID) is a common ageing-related endocrinopathy estimated to affect 15– 30% of aged horses. Measurement of adrenocorticotropic hormone (ACTH) concentration is the most popular means of diagnosing PPID and has reasonable accuracy; however, increasing evidence and consensus of expert opinion indicates a need for revision of how ACTH test results are interpreted and a need for replacement of basal ACTH concentration with measurement of ACTH concentration following the administration of thyrotropin releasing hormone (TRH) in all horses that do not have obvious clinical signs [1]. Assessment of insulin dysregulation should be routine in the diagnosis and monitoring of PPID but is frequently overlooked ...
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Affiliation of the authors at the time of publication
Rainbow Equine Lab, Rainbow Equine Hospital, Malton, North Yorkshire, YO17 6SG, UK.
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