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Diagnostic Tests for a Predisposition to Laminitis
N. Menzies-Gow
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Introduction
Laminitis most often arises in association with pasture, although gastrointestinal disease, endotoxaemia and endocrine disorders can be risk factors. Certain individual animals appear predisposed to recurrent laminitis, but the exact mechanisms underlying their predisposition remains a fundamental question in laminitis research. It seems likely that there are certain phenotypic traits common to these individuals. Multiple variables have been evaluated as risk factors for laminitis with the findings generally being inconsistent between studies. An association between the occurrence of laminitis and being a pony, the spring and summer months (Hinckley and Henderson 1996), being female, increased age (Alford et al. 2001) and obesity (Johnson et al. 2004; Treiberet al. 2005a) have been demonstrated in some studies. The most likely endocrinological disorders that may play a role in this predisposition are those associated with excess glucocorticoids, specifically pituitary pars intermedia dysfunction, and those associated with insulin resistance (IR), namely equine metabolic syndrome (Johnson et al. 2004). However, it must be remembered that not all laminitis prone animals have an underlying endocrinopathy. [...]
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