Applications of Metabolomics in Veterinary Pharmacology Research: Advantages, Limitations and Future Perspectives

Introduction
Inter-individual variability in drug response upon drug administration is caused by the interaction between drug pharmacology and patients’ (patho)physiological status. Individual variations in (patho)physiological status may result from, breed, genetic polymorphisms, age, sex, gut microbiota, disease-related factors, and environmental factors. Identification and quantification of predictors of inter-individual variability in drug pharmacology can expedite veterinary drug discovery. Also, predictors of individual responses to a particular drug can inform clinicians in decision-making process for drug selection and drug dosing regimens. Current research reveals that the metabolome can contain predictors of inter-individual differences in drug response. [...]