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A Lack of Cytochrome P450 Probes for Veterinary Species and what it Means for in vitro Drug Metabolism Studies and Veterinary Drug Development
C. Locuson
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Cytochromes P450 are a family of heme-containing enzymes well-known for their role in the metabolism of drugs and other xenobiotics. Drug metabolism by cytochromes P450 affects drug disposition in a variety of ways, which collectively, are related to the efficacy and safety profiles of pharmaceuticals. Where a drug is cleared in part by oxidative metabolism, hepatic P450 enzymes are often involved due to the abundance of P450s in the liver. As such, several liver-derived enzyme preparations have been used to study the P450 biotransformations of drug-like compounds in vitro. Common preparations, listed in increasing complexity, include liver microsomes, hepatocytes, liver slices, and perfused liver. […]
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About
Affiliation of the authors at the time of publication
Chuck Locuson, PhD, Pfizer Animal Health, Metabolism & Safety, MI, USA.
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