AAEP Annual Convention San Antonio 2011
Back to Table of Contents
Add to My Library
Comments
Share:

Induction of Ovulation in Seasonally Anestrous Mares Using Recombinant Equine Follicle-Stimulating Hormone

Author(s):
Roser J.F.,
Troedsson M.,
McCue P.,
Klein C.,
Ferris R.A.,
Meyers-Brown G.A.,
Zent W.W.,
Lindholm A.R.G.,
Scofield D.B.,
Claes A.N.J.,
Colgin M.,
Morganti M.,
Wetzel R.L. and
Peters A.R.
In: AAEP Annual Convention - San Antonio, 2011 by American Association of Equine Practitioners
Updated:
NOV 22, 2011
Languages:
Back to Table of Contents
Add to My Library

Administration of recombinant equine follicle-stimulating hormone was effective in stimulating development of follicles and advancing the first ovulation of the year in anestrous mares under ambient lighting conditions. Authors’ addresses: University of California, One Shields Avenue, Davis, CA 95616 (Roser, Meyers-Brown, Claes, Morganti); University of Kentucky, 1400 Nicholasville Road, Lexington, KY 40546 (Troedsson, Klein); Colorado State University, 3103 Rampart Road, Fort Collins, CO 80521 (McCue, Ferris); AspenBio Pharma, Inc., 1585 South Perry Street, Castle Rock, CO 80104 (Colgin, Wetzel, Peters); e-mail: jfroser@ucdavis.edu.

1. Introduction

The aim of the study was to determine the efficacy of recombinant equine follicle stimulating hormone (reFSH) in stimulating follicular development and advancing the first ovulation of the year in seasonally anestrous mares under ambient lighting conditions.

2. Materials and Methods

Sixty university-owned anestrous mares, maintained under natural lighting conditions, were randomly allocated to group A or B. All were examined by transrectal ultrasound to confirm that all ovarian follicles were ≤20 mm in diameter. Starting on January 31, group A mares received twice-daily IM injections of 0.65 mg reFSHa  in 1.3 mL PBS and group B received 1.3 mL PBS IM as negative control. Treatments were blinded, and subsequent follicular development was closely monitored by ultrasound. When the largest follicle reached ≥35 mm, reFSH treatment was discontinued and 2500 IU human chorionic gonadotropin (hCG) was injected IV 36 hours later to induce ovulation. 

3. Results

All 30 mares receiving reFSH developed follicles ≥ 35 mm within 7.4 ± 1.6 days of treatment. Twenty-three of the 30 reFSH-treated mares ovulated within 72 hours after human chorionic gonadotropin (hCG) administration. In contrast, mares in group B (placebo treatment) did not exhibit significant follicular development, and none ovulated during the 15-day observation period.

4. Discussion

These data indicate that reFSH was effective in stimulating development of ovarian follicles and advancing the first ovulation of the year in seasonally anestrous mares under ambient lighting conditions. This product is not yet commercially available.

Funding was provided by AspenBio Pharma, Inc., Castle Rock, CO.

Footnote

a AspenBio Pharma, Inc., Castle Rock, CO 80104.

View full text
Back to Table of Contents
Add to My Library

Ask the author

0 comments
Submit

How to reference this publication (Harvard system)?

Roser, J. F. et al. (2011) “Induction of Ovulation in Seasonally Anestrous Mares Using Recombinant Equine Follicle-Stimulating Hormone”, AAEP Annual Convention - San Antonio, 2011. Available at: https://www.ivis.org/library/aaep/aaep-annual-convention-san-antonio-2011/induction-of-ovulation-seasonally-anestrous-mares-using-recombinant-equine-follicle-stimulating (Accessed: 03 June 2023).

Affiliation of the authors at the time of publication

University of California, One Shields Avenue, Davis, CA 95616 (Roser, Meyers-Brown, Claes, Morganti); University of Kentucky, 1400 Nicholasville Road, Lexington, KY 40546 (Troedsson, Klein); Colorado State University, 3103 Rampart Road, Fort Collins, CO 80521 (McCue, Ferris); AspenBio Pharma, Inc., 1585 South Perry Street, Castle Rock, CO 80104 (Colgin, Wetzel, Peters), USA

Author(s)

Copyright Statement

© All text and images in this publication are copyright protected and cannot be reproduced or copied in any way.

Readers also viewed these publications

Provided by:

The AAEP represents nearly 9,300 veterinarians and veterinary students in 61 countries who cover a broad range of equine disciplines, breeds and associations. The AAEP is primary resource for education, professional development and ethical standards for its members. The AAEP and its members are recognized as the voice and authority for the health and welfare of the horse. The AAEP conducts regular strategic planning every three to four years in order to establish priorities and set direction for the association over the current planning horizon.  The AAEP is a respected source of information for influencing public policy.  

Learn more
Back To Top