AAEP Annual Convention San Antonio 2011
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Dose Titration of the Clinical Efficacy of Intravenous Phenylbutazone in a Reversible Model of Equine Foot Lameness

Author(s):
Foreman J.H. and
Seino K.K.
In: AAEP Annual Convention - San Antonio, 2011 by American Association of Equine Practitioners
Updated:
NOV 22, 2011
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Half-dose phenylbutazone was clinically effective for only a brief period compared with full or double doses. During the 12-hour monitoring period, there was no added analgesic benefit to giving a potentially toxic double dose of phenylbutazone in this model of acute foot pain. Authors’ address: University of Illinois, Urbana, IL 61802; e-mail: [email protected]. *Corresponding author. © 2011 AAEP.

1. Introduction

The objective of this experiment was to compare the clinical efficacy of various doses of phenylbutazone (PBZ) with a negative control. The hypothesis was that higher PBZ doses would result in improved efficacy in a dose-dependent manner when tested in a reversible model of foot lameness.

2. Materials and Methods

Eight horses were shod with adjustable heart bar shoes on one front foot. Weekly grade 4.0/5.0 lameness was induced by tightening a set screw against the heart bar. Heart rate (HR) and lameness score (LS) were monitored at rest; every 20 minutes after lameness induction for 5 hours; and hourly for another 8 hours. One hour after lameness induction, treatment was administered intravenously in a randomized, blinded manner and included negative control (isotonic saline: SAL) or PBZ at 2.2 (half dose), 4.4 (full dose), or 8.8 (double dose) mg/kg. Results were compared using repeated-measures ANOVA and Student-Newman-Keul test with the level of significance set at p < 0.05. 

3. Results

HR and LS changes mirrored one another. Full- and double-dose PBZ reduced HR from 3.0 to 12.0 hours after administration (p < 0.05); there was no difference in response between full- and double-dose PBZ. Compared with SAL, half-dose PBZ reduced HR from 3.67 to 5.0 hours (p < 0.05) and reduced LS from 3.67 to 4.0 hours (p < 0.05) after administration.

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How to reference this publication (Harvard system)?

Foreman, J. and Seino, K. (2011) “Dose Titration of the Clinical Efficacy of Intravenous Phenylbutazone in a Reversible Model of Equine Foot Lameness”, AAEP Annual Convention - San Antonio, 2011. Available at: https://www.ivis.org/library/aaep/aaep-annual-convention-san-antonio-2011/dose-titration-of-clinical-efficacy-of-intravenous-phenylbutazone-a-reversible-model-of-equine-foot (Accessed: 15 October 2024).

Author(s)

  • J.H. Foreman

    Foreman J.H.

    Associate Dean, Professor
    BS, DVM, MS, DACVIM
    Large Animal Clinic, College of Veterinary Medicine, University of Illinois at Urbana-Champaign
    Read more about this author

  • Seino K.K.

    DVM, MS
    College of Veterinary Medicine, University of Florida
    Read more about this author

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