AAEP Annual Convention San Antonio 2011
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Clinical and Pharmacokinetic Effects of Regional or General Anesthesia on Equine Amikacin Regional Limb Perfusion

Author(s):

A.T. Mahne, L.M. Rubio-Martinez, E...

In: AAEP Annual Convention - San Antonio, 2011 by American Association of Equine Practitioners
Updated:
NOV 22, 2011
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Perineural regional anesthesia during intravenous regional limb perfusion improves the comfort of horses. Regional pharmacokinetic parameters were similar in all groups. Authors’ addresses: University of Pretoria, Onderstepoort, 0110 South Africa (Mahne, Rubio-Martinez, Rioja, Marais); Comparative and Experimental Medicine, University of Tennessee, Knoxville, TN 37996- 4550 (Villarino); e-mail: [email protected].

1. Introduction

Antimicrobial intravenous regional limb perfusion (IVRLP) is clinically performed on anesthetized or sedated horses with or without regional anesthesia. This study examined the clinical and regional pharmacokinetic effects of regional or general anesthesia (GA) on IVRLP with amikacin.

2. Materials and Methods

Eight healthy horses received four treatments of amikacin IVRLP in a randomized, blinded, crossover study: under GA, under standing sedation (SED) without regional anesthesia (CNT), SED with perineural regional anesthesia (PNA) or SED with intravenous regional anesthesia (IVA). Synovial fluid amikacin concentrations were measured over 24 hours, and the regional pharmacokinetic parameters (rPkp) was calculated. Heart and respiratory rates, visual analogue scale (VAS) of discomfort, number of times the limb was lifted (LIFT), and number of extra sedations administered were recorded. ANOVA cross-over analysis was applied. Significance was set at p < 0.05.

3. Results

Amikacin concentrations and rPkp did not differ significantly among treatments. Scores of VAS (mean ± SD) were significantly lower with PNA (18 ± 15) versus IVA (68 ± 33) and CNT (82 ± 13). Significantly lower LIFT (median [range]) occurred with PNA (12.5 [4 to 64]) versus CNT (53 [15 to 85]). No extra sedation was administered in PNA. Heart and respiratory rates were similar among treatments.

4. Discussion

IVRLP with PNA in sedated horses is an effective and economical way to improve comfort of horses without significantly affecting the rPkp of amikacin.

Acknowledgment

Bayer HealthCare, Pfizer Animal Health, and Roche Products supplied materials.

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Affiliation of the authors at the time of publication

University of Pretoria, Onderstepoort, 0110 South Africa (Mahne, Rubio-Martinez, Rioja, Marais); Comparative and Experimental Medicine, University of Tennessee, Knoxville, TN 37996- 4550, USA (Villarino)

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