AAEP Annual Convention Las Vegas 2009
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Pharmacokinetics of Intravenous and Subcutaneous Ceftiofur Sodium in Neonatal Foals

Author(s):

T.L. Hall, L.A. Tell, L.W. Fowler...

In: AAEP Annual Convention - Las Vegas, 2009 by American Association of Equine Practitioners
Updated:
DEC 09, 2009
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1. Introduction
Ceftiofur sodium is a third generation cephalosporin approved by the Food and Drug Administration for IM administration in horses. Clinicians administer this antibiotic by IV or SC routes in septicemic foals. The objective of this study was to determine the pharmacokinetics of ceftiofur sodium administered either IV or SC in neonatal foals.

2. Materials and Methods
Twelve foals were randomly assigned to one of two groups to receive 5 mg/kg body weight of ceftiofur sodium administered one time either IV or SC. Plasma samples were collected at set intervals for 12 h after drug administration. Concentrations of ceftiofur free-acid equivalents (CFAE) were determined by high-performance liquid chromatography. [...]

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Affiliation of the authors at the time of publication

William D. Pritchard Veterinary Medical Teaching Hospital, School of Veterinary Medicine, University of California at Davis, Davis, California 95616, USA (Fowler, Hall); and the Department of Medicine and Epidemiology, School of Veterinary Medicine, University of California at Davis, Davis, California 95616, USA (Pusterla, Tell)

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