AAEP Annual Convention Las Vegas 2009
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Evaluation of Serological Responses in Primed Pre-Partum Broodmares Post-Vaccination with a West Nile Virus Vaccine (Live Flavivirus Chimera)

Author(s):
Gutierrez C.,
Brown II S.E.,
Beachboard S.E. and
Long M.T.
In: AAEP Annual Convention - Las Vegas, 2009 by American Association of Equine Practitioners
Updated:
DEC 09, 2009
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1. Introduction
This study investigated the response of previously vaccinated gravid broodmares to a chimeric West Nile virus (WNV) vaccine. The three goals were (1) to show if low-titer mares responded appropriately (four-fold change in titer) during gestation, (2) to show if high-titer mares had antivector immunity to this modified-live vaccine, and (3) to confirm that this vaccine can be used in pregnant mares to induce colostral immunity

2. Materials and Methods
On day 0, a single dose of Prevenilea was administered IM to 81 broodmares within 4–8 wk of foaling. Before vaccination, whole blood samples were obtained and allowed to clot. The serum was collected and stored until assayed. On day 21, additional serum blood samples were obtained, and paired titers were evaluated.

3. Results
Eighty-one horses had both samples obtained at 3 wk post-vaccination. All of the mares showed a significantly increased titer level post-vaccination. All mares, even if low at the first sampling, had a four-fold rise in titer, which indicates an anamestic response. [...]

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How to reference this publication (Harvard system)?

Gutierrez, C. et al. (2009) “Evaluation of Serological Responses in Primed Pre-Partum Broodmares Post-Vaccination with a West Nile Virus Vaccine (Live Flavivirus Chimera)”, AAEP Annual Convention - Las Vegas, 2009. Available at: https://www.ivis.org/library/aaep/aaep-annual-convention-las-vegas-2009/evaluation-of-serological-responses-primed-pre-partum-broodmares-post-vaccination-a-west-nile-virus (Accessed: 04 October 2023).

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