AAEP Annual Convention Las Vegas 2009
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Evaluation of Regional Limb Perfusion with Amikacin Using the Saphenous, Cephalic, and Palmar Digital Veins

Author(s):

G. Kelmer, G.C. Bell, T. Martin...

In: AAEP Annual Convention - Las Vegas, 2009 by American Association of Equine Practitioners
Updated:
DEC 09, 2009
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1. Introduction
Previous studies have shown that regional limb perfusion (RLP) using the palmar digital (PD) vein will deliver therapeutic concentration of amikacina  to the distal limb. Our hypothesis was that using the cephalic and saphenous veins for RLP will enable delivery of therapeutic concentrations of amikacin to the distal limb.

2. Materials and Methods
Nineteen healthy research horses participated in the study. One randomly selected thoracic or pelvic limb from each horse was used for RLP. The cephalic, saphenous, or PD vein was used to perfuse the limb with amikacin. Two grams of amikacin were used for RLP through the saphenous and cephalic veins, and 1 g was used in the PD vein. Synovial samples were collected from the metacarpo/metatarso-phalangeal (MCP/MTP) joint, and serum samples were collected from the jugular vein.

3. Results
Maximum concentration (Cmax) of amikacin in the MCP/MTP joint using the cephalic and saphenous veins were 277 and 363 mg/l, respectively. [...]

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Affiliation of the authors at the time of publication

Large Animal Clinical Sciences, University of Tennessee, College of Veterinary Medicine, Knoxville, Tennessee 37996, USA (Kelmer, Catasus, Elliott); Health Science Center, University of Tennessee, College of Pharmacy, Memphis, Tennessee 38105, USA (Bell, Meibohm); Comparative Medicine, University of Tennessee, College of Veterinary Medicine, Knoxville, Tennessee 37996, USA (Martin-Jimenez); and Animal Science, University of Tennessee, College of Agricultural Sciences and Natural Resources, Knoxville, Tennessee, 37996, USA (Saxton)

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