AAEP Annual Convention Las Vegas 2009
Back to Table of Contents
Add to My Library
Comments
Share:

Evaluation of Dimethyl Sulfoxide Effects on Endotoxin-Induced Delayed Gastric Emptying in Horses

Author(s):

G. Kelmer, T.J. Doherty, S.B...

In: AAEP Annual Convention - Las Vegas, 2009 by American Association of Equine Practitioners
Updated:
DEC 09, 2009
Languages:
Back to Table of Contents
Add to My Library

1. Introduction
Endotoxemia is one of the most severe and ubiquitous disease processes in horses, and delayed gastric emptying is one of the most significant manifestations of endotoxemia. Oxidative damage plays a key role in the systemic effects induced by endotoxin, and thus, antioxidants, such as dimethyl sulfoxide (DMSO), might have a protective effect.

2. Materials and Methods
Eighteen horses were randomly assigned to one of four groups: Normosolb + lipopolysaccharidea (LPS) (0.2 μg/kg, IV), DMSOc  (1 g/kg, IV) + Saline, high-dose DMSO (1 g/kg, IV) + LPS, and low-dose DMSO (20 mg/kg, IV) + LPS. Horses not receiving LPS were reassigned to a LPS group after a 2-wk washout period. All horses received acetaminophend  (20 mg/kg in 1l tap water) by nasogastric intubation. Data for acetaminophen concentrations in the blood as a measure of gastric emptying were examined for the effect of treatment using a repeated-measures mixed-model analysis of variance. A value of p < 0.05 was considered significant. [...]

View full text
Back to Table of Contents
Add to My Library

Ask the author

0 comments
Submit

Affiliation of the authors at the time of publication

Department of Large Animal Clinical Sciences, College of Veterinary Medicine, University of Tennessee, 2407 River Drive, Knoxville, Tennessee 37996, USA (Kelmer, Doherty, Elliott); Department of Comparative Medicine, College of Veterinary Medicine, University of Tennessee, 2407 River Drive, Knoxville, Tennessee 37996, USA (MartinJimenez); Department of Animal Science, College of Agricultural Sciences and Natural Resources, University of Tennessee, 2407 River Drive, Knoxville, Tennessee 37996, USA (Saxton); and Department of Veterinary Clinical Sciences, Equine Health Studies Program, Louisiana State University, School of Veterinary Medicine, Skip Bertman Drive, Baton Rouge, Louisiana 70803, USA (Andrews)

Copyright Statement

© All text and images in this publication are copyright protected and cannot be reproduced or copied in any way.

Readers also viewed these publications

Provided by:

The AAEP represents nearly 9,300 veterinarians and veterinary students in 61 countries who cover a broad range of equine disciplines, breeds and associations. The AAEP is primary resource for education, professional development and ethical standards for its members. The AAEP and its members are recognized as the voice and authority for the health and welfare of the horse. The AAEP conducts regular strategic planning every three to four years in order to establish priorities and set direction for the association over the current planning horizon.  The AAEP is a respected source of information for influencing public policy.  

Learn more
Back To Top