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Efficacy of Furosemide for Prevention of Exercise-Induced Pulmonary Hemorrhage in Thoroughbred Racehorses
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1. Introduction
The objective of this study was to evaluate the efficacy of furosemide for prevention of exercise-induced pulmonary hemorrhage (EIPH) in Thoroughbred racehorses under typical racing conditions.
2. Materials and Methods
This was a randomized, placebo-controlled, blinded, cross-over field trial using 167 Thoroughbred racehorses. Horses were randomly allocated to race fields of 9–16 horses each and raced twice, 1 wk apart, with each of the two races consisting of the same race field and distance. Each horse received furosemide (500 mg, IV) before one race and a placebo (saline solution) before the other race, and severity of EIPH was scored on a scale from 0 to 4 after each race by means of tracheobronchoscopy. Data were analyzed using several forms of multivariable logistic regression. [...]
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