AAEP Annual Convention Las Vegas 2009
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Effects of Suxibuzone and Phenylbutazone on Development of Gastric Ulcers in Horses

Author(s):
Andrews F.M.,
Reinemeyer C.R. and
Longhofer S.L.
In: AAEP Annual Convention - Las Vegas, 2009 by American Association of Equine Practitioners
Updated:
DEC 09, 2009
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1. Introduction
Phenylbutazone (PBZ) and its derivative compound suxibuzone (SBZ) are commonly used to treat pain and inflammation in horses because of their analgesic and anti-inflammatory properties and history of safe use.1,2 These agents are usually given orally because of safety and practical considerations and both are available as top-dress formulations.

Gastric ulcers from PBZ administration are the result of both local and systemic mechanisms.3  Systemic toxicity seems to result from vasoconstriction related to prostaglandin inhibition or from toxic effects to the endothelium and local defenses (e.g., decreased mucin production).4  The local mechanism is related to rapid uptake by and direct damage to mucosal cells. Therefore, formulations of PBZ that avoid local irritation, such as enterically coated or pro-drug formulations, are generally considered to be better tolerated.3  Suxibuzone is a pro-drug that is systemically metabolized to PBZ, thereby bypassing local toxic effects on gastric mucosa. Consequently, SBZ should be at least as safe as PBZ regarding formation of gastric ulcers.3  This study compares the ulcerogenicity of top-dress formulations containing either PBZ or SBZ. [...]

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How to reference this publication (Harvard system)?

Andrews, F., Reinemeyer, C. R. and Longhofer, S. (2009) “Effects of Suxibuzone and Phenylbutazone on Development of Gastric Ulcers in Horses”, AAEP Annual Convention - Las Vegas, 2009. Available at: https://www.ivis.org/library/aaep/aaep-annual-convention-las-vegas-2009/effects-of-suxibuzone-and-phenylbutazone-on-development-of-gastric-ulcers-horses (Accessed: 30 November 2023).

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