AAEP Annual Convention Las Vegas 2009
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Cloprostenol: Something More Than a Luteolytic Drug

Author(s):

J. Cuervo-Arango, J.R. Newcombe

In: AAEP Annual Convention - Las Vegas, 2009 by American Association of Equine Practitioners
Updated:
DEC 09, 2009
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1. Introduction
Prostaglandin F2α (PGF) and its analogs are widely used in equine reproductive practice. The interval from PGF treatment to ovulation (ITO) varies greatly, with a range from 2 to 16 days. Clinical observations suggest that mares mated and ovulated soon after PGF treatment may have poor fertility.

2. Materials and Methods
Reproductive records of 329 cyclic Thoroughbred mares were analyzed retrospectively. The following parameters were analyzed: (1) use of cloprostenol; (2) ITO; and (3) number of ovulations per cycle. According to these parameters, mares were classified into four groups: (1) mares with spontaneous ovulations (n = 57); (2) mares treated with cloprostenol and ITO = 4–7 days (n = 77); (3) ITO = 8–10 days (n = 89); and (4) ITO ≥ 11 days (n = 106). Differences in pregnancy (PR) and multiple ovulation (MO) rates among groups were analyzed using the chi-square test.

3. Results
PR for groups 1–4 were as follows: 73.7%, 46.7%, 64%, and 71.7%, respectively. PR for group 2 was significantly lower (p < 0.05) than PR for groups 1, 3, and 4. Groups 1 and 2 had lower (p < 0.05) MO rates (24.6% and 20.8%, respectively) than groups 3 and 4 (40.4% and 44.3%, respectively). [...]

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Affiliation of the authors at the time of publication

Warren House Farm Equine Fertility Clinic, Brownhills, WS8 6L5, United Kingdom (Cuervo-Arango, Newcombe); and Departamento de Cirugía y Medicina Animal, Facultad de Ciencias Experimentales y de la Salud, Universidad Cardenal Herrera-CEU, Moncada, 46113, Spain (Cuervo-Arango)

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