AAEP Annual Convention Las Vegas 2009
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Bioactivity of 5α-Dihydroprogesterone in Mares: Endometrial Response and Maintenance of Early Pregnancy

Author(s):

E.L. Scholtz, B.A. Ball, S.D...

In: AAEP Annual Convention - Las Vegas, 2009 by American Association of Equine Practitioners
Updated:
DEC 09, 2009
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1. Introduction
The purpose of this study was to examine the progestogenic effect of 5α-dihydroprogesterone (5α-DHP) on the endometrium and to assess its ability to maintain early pregnancy in the mare.

2. Materials and Methods
In experiment 1, ovariectomized mares (n = 4) were treated daily with 5α-DHPa  (300 mg, IM) or vehicle for 10 days in a crossover design. Endometrial biopsies were taken immediately before the first administration of 5α-DHP and 24 h after the last administration for routine histology and detection of the progesterone-responsive protein, lipocalin (P19). In experiment 2, mares with confirmed day 12 pregnancies (day 0 = ovulation) were treated daily with 5α-DHP (0.7 mg/kg, IM; n = 9) or vehicle (n = 5), beginning on day 13. On day 14, mares were given PGF2αb  (10 mg, IM) to eliminate endogenous progesterone. Plasma concentrations of progesterone and 5α-DHP were measured daily by liquid chromatography–mass spectrometry (LC-MS). [...]

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Affiliation of the authors at the time of publication

Department of Population Health and Reproduction (Scholtz, Ball, Conley) and K.L. Maddy Equine Analytical Chemistry Laboratory, California Animal Health and Food Safety Laboratory (Stanley, Moeller), School of Veterinary Medicine, University of California, Davis, California 95616, USA

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