AAEP Annual Convention Las Vegas 2009
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An Accelerated Vaccination Schedule for Use in an Equine Influenza Emergency Response

Author(s):

C.M. El-Hage, C.J. Savage, J.M...

In: AAEP Annual Convention - Las Vegas, 2009 by American Association of Equine Practitioners
Updated:
DEC 09, 2009
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1. Introduction
Measures to rapidly contain virus spread and provide immunological protection are vital to control outbreaks of equine influenza (EI) in susceptible horse populations. An accelerated vaccination schedule has been used during the recent EI outbreaks in South Africa and Australia. No published efficacy data were available to date.

2. Materials and Methods
Fourteen naïve Thoroughbreds were vaccinated with a recombinant canarypox-vectored equine influenza vaccine (rCP-EIVa ) that expressed the haemagglutinin gene of two H3N8 EI viruses (A/eq/ Newmarket/2/93 and A/eq/Kentucky/94). Horses were vaccinated on days 0, 14, and 105. Blood samples were collected immediately before each vaccination and on days 42, 56, 147, and 224. Antibody was detected by single radial hemolysis and hemagglutination inhibition. Absence of concomitant EI infection was confirmed by enzyme-linked immunosorbent assay (ELISA). [...]

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Affiliation of the authors at the time of publication

Equine Centre, The University of Melbourne, 250 Princes Highway, Werribee, Victoria 3030, Australia (El-Hage, Savage); Merial SAS, rue Marcel Mérieux, Lyon, 69007 France (Minke); and Equine Infectious Disease Laboratory, Veterinary Pre-Clinical Centre, The University of Melbourne, Parkville, Victoria 3010, Australia (Ficorilli, Gilkerson)

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