AAEP Annual Convention Anaheim 2012
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A Dietary Nutraceutical Product Reduces Synovial Fluid Prostaglandin E2 in Horses with Osteoarthritis: A Double-Blind, Randomized Trial

Author(s):

W. Pearson, N. Cote, M. Desjardins

In: AAEP Annual Convention - Anaheim, 2012 by American Association of Equine Practitioners
Updated:
DEC 05, 2012
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A dietary nutraceutical product may be a useful postsurgical treatment for elevated prostaglandin E2 in horses with surgical removal of osteochondral fragments.

1. Introduction

A dietary nutraceutical producta  (DN) has previously demonstrated prophylactic prostaglandin E2 (PGE2)- inhibitory effects in interleukin (IL)-1–stimulated cartilage explants and in horses with experimentally induced articular inflammation. The current study was undertaken to evaluate the therapeutic effect of including DN in the diet of horses with articular inflammation and/or cartilage damage secondary to osteochondral fragmentation of the carpal or metacarpal joints.

2. Hypothesis or Objectives

It was hypothesized that inclusion of DN in the diet of horses immediately after surgical removal of osteochondral fragment would reduce synovial fluid PGE2, nitric oxide (NO), and glycosaminoglycan (GAG), while improving clinical signs of articular inflammation in these horses.

3. Methods

Fifteen horses presenting at an equine hospital for surgical removal of an osteochondral fragment of the carpal or metacarpal joints were included. Horses received DN (0 or 21 g/d) for 42 days, beginning immediately after surgery. Synovial fluid before and after supplementation was analyzed for PGE2, GAG, and NO. Radiographs and lameness assessments were also obtained. 

4. Results

Synovial fluid PGE2 was significantly reduced from baseline in horses receiving DN, but not in those horses treated with surgery alone. There was no difference between treatments on GAG, NO, radiographs, or lameness grade.

5. Conclusions

These data support previously published experimental evidence of an inhibitory effect of DN on synovial fluid PGE2. In the current study, DN effectively reduced synovial fluid PGE2 in horses with surgical removal of osteochondral fragments.

This research was funded by Interpath Pty Ltd (Ballarat Australia).

Footnote

a Sashas EQ™, Interpath Ballarat, Victoria Australia 3353.

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Affiliation of the authors at the time of publication

Department of Plant Agriculture, University of Guelph, Equine Sciences Building, 50 McGilvray Street, Guelph, ON N1G 2W1, Canada (Pearson); and Milton Equine Hospital, 10207 Guelph Line, Campbellville, ON L0P 1B0, Canada (Cote, Desjardins)

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