Key information
DNA damage response mechanisms protect mammalian cells from genomic instability and phenotypes such as aging and cancer. In contrast to normal cells, tumors exhibit extreme genomic instability, which can occur at the level of DNA as well as at the chromosomal level. This course reviews the causes and consequences of genomic instability, including manifestations in DNA and chromosomes; the course also provides a thorough review of cellular DNA damage response mechanisms, including detection of damage, checkpoint signaling, and recruitment of repair factors.
Learning Objectives
- List causes and consequences of genomic instability
- Define the following and explain their significance in cancer: chromosomal deletion, chromosomal translocation, chromosomal inversion, aneuploidy, polyploidy, internal tandem duplication and provide key examples
- Explain the difference between and the significance of somatic and germline mutations
- Describe the differences between single strand and double strand DNA breaks in terms of impact on the cell and repair processes involved
- Name the kinases involved in signaling for DNA damage
- Explain the following: mismatch repair, nucleotide excision repair, base excision repair, microsatellite instability. Name cancers or cancer syndromes associated with deficiencies in these repair processes
- Recognize the key players in checkpoint signaling and DNA repair including the DNA damage response pathway components that are currently undergoing evaluation as therapeutic targets
Presenter - Kelly R. Hume, DVM, DACVIM (Oncology)
- Associate Professor, Department of Clinical Sciences
- Cornell University
The ACVIM has developed nine (9) Science of Veterinary Oncology (SOVO) online courses that are currently available and complimentary for ACVIM members with five (5) more in development and coming soon. These modules offer foundational building blocks of core knowledge areas pertaining to veterinary oncology and were developed based on the Job Task Analysis review performed in 2016. All modules are led by industry experts and each module is RACE-approved.
All Sessions:
- Cancer Bioenergetics - Douglass H. Thamm, VMD, DACVIM (Oncology)
- Cancer Stem Cells - Professor David Argyle, PhD and Lisa Pang, PhD
- Cell Signaling and Signal Transduction Inhibitors - Cheryl London, DVM, PhD, DACVIM (Oncology)
- Discovery and Evaluation of Anticancer Drugs - David Lowery, PhD
- Epigenetics of Cancer - Jeffrey Bryan, DVM, MS, Phd, DACVIM (Oncology)
- Genomic Instability - Kelly R. Hume, DVM, DACVIM (Oncology)
- Invasion and Metastasis - Robert B. Rebhun, DVM, PhD, DACVIM (Oncology)
- Pharmacology of Cancer Drugs and Resistance - Luke Wittenburg, DVM, PhD, DACVCP
- Tumor Microenvironment - Jamie Modiano, VMD, PhD
