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In:  Equine Respiratory Diseases.  P. Lekeux (Ed.)

Publisher:  International Veterinary Information Service, Ithaca, New York, USA.

Recurrent Airway Obstruction (Heaves)
N. E. Robinson

References

 
1.  Robinson NE, Derksen FJ, Olszewski MA, et al. The pathogenesis of chronic obstructive pulmonary disease of horses. Br Vet J 1995; 152:283-306. - PubMed -
 
2.  Seahorn TL, Beadle RE. Summer pasture-associated obstructive pulmonary disease in horses: 21 cases (1983-1991). J Am Vet Med Assoc 1993; 202:779-782. - PubMed -
 
3.  Seahorn TL, Groves MG, Harrington KS, et al. Chronic obstructive pulmonary disease in horses in Louisiana. J Am Vet Med Assoc 1996; 208:248-251. - PubMed -
 
4.  Robinson NE. Chairperson's introduction: International Workshop on Equine Chronic Airway Disease, Michigan State University, 16-18 June 2000. Equine Vet J 2001; 33:5-19.
 
5.  Woods PS, Robinson NE, Swanson MC, et al. Airborne dust and aeroallergen concentration in a horse stable under two different management systems. Equine Vet J 1993; 25:208-13. - PubMed -
 
6.  Vandenput S, Istasse L, Nicks B, et al. Airborne dust and aeroallergen concentrations in different sources of feed and bedding for horses. Vet Quarterly 1997; 19:154-158. - PubMed -
 
7.  McGorum BC, Ellison J, Cullen RT. Total and respirable airborne dust endotoxin concentrations in three equine management systems. Equine Vet J 1998; 30:430-434. - PubMed -
 
8.  Halliwell REW, McGorum BC, Irving P, et al. Local and systemic antibody production in horses affected with chronic obstructive pulmonary disease. Vet Immunol Immunopathol 1993; 38:201-215. - PubMed -
 
9.  Seahorn TL, Beadle RE, McGorum BC, et al. Quantification of antigen-specific antibody concentrations in tracheal lavage fluid of horses with summer pasture-associated obstructive pulmonary disease. Am J Vet Res 1997; 58:1408-11. - PubMed -
 
10.  Lavoie JP, Maghni K, Desnoyers M, et al. Neutrophilic Airway Inflammation in Horses with Heaves Is Characterized by a Th2-type Cytokine Profile. Am J Respir Crit Care Med 2001; 164:1410-3. - PubMed -
 
11.  Derksen FJ, Scott JS, Slocombe RF, et al. Micropolyspora faeni causes airway inflammation but not hyperresponsiveness in sensitized ponies. J Appl Physiol 1987; 62:1398-1404. - PubMed -
 
12.  Derksen FJ, Robinson NE, Scott JS, et al. Aerosolized Micropolyspora faeni antigen as a cause of pulmonary dysfunction in ponies with recurrent airway obstruction (heaves). Am J Vet Res 1988; 49:933-938. - PubMed -
 
13.  McGorum BC, Dixon PM, Halliwell REW. Responses of horses affected with chronic obstructive pulmonary disease to inhalation challenges with mould antigens. Equine Vet J 1993; 25:261-267. - PubMed -
 
14.  Wagner JG, Van Dyken SJ, Hotchkiss JA, et al. Endotoxin enhancement of ozone-induced mucous cell metaplasia is neutrophil-dependent in rat nasal epithelium. Toxicol Sci 2001; 60:338-47. - PubMed -
 
15.  Donaldson K, Stone V, Clouter A, et al. Ultrafine particles. Occup Environ Med 2001; 58:211-6, 199.
 
16.  Tsuda A, Stringer BK, Mijailovich SM, et al. Alveolar cell stretching in the presence of fibrous particles induces interleukin-8 responses. Am J Respir Cell Mol Biol 1999; 21:455-62. - PubMed -
 
17.  Marti E, Gerber H, Essich G, et al. The genetic basis of equine allergic diseases 1. Chronic hypersensitivity bronchitis. Equine Vet J 1991; 23:457-460. - PubMed -
 
18.  Derksen FJ, Scott JS, Miller DC, et al. Bronchoalveolar lavage in ponies with recurrent airway obstruction (heaves). Am Rev Respir Dis 1985; 132:1066-1070. - PubMed -
 
19.  McGorum BC, Dixon PM, Halliwell REW, et al. Comparison of cellular and molecular components of bronchoalveolar lavage fluid harvested from different segments of the equine lung. Res Vet Sci 1993; 55:57-59. - PubMed -
 
20.  Franchini M, Gill U, von Fellenberg R, et al. Interleukin-8 concentration and neutrophil chemotactic activity in bronchoalveolar lavage fluid of horses with chronic obstructive pulmonary disease following exposure to hay. Am J Vet Res 2000; 61:1369-74. - PubMed -
 
21.  Franchini M, Gilli U, Akens MK, et al. The role of neutrophil chemotactic cytokines in the pathogenesis of equine chronic obstructive pulmonary disease (COPD). Vet Immunol Immunopathol 1998; 66:53-65. - PubMed -
 
22.  Bureau F, Bonizzi G, Kirschvink N, et al. Correlation between nuclear factor-kB activity in bronchial brushing samples and lung dysfunction in an animal model of asthma. Am J Respir Crit Care Med 2000; 161:1314-1321. - PubMed -
 
23.  Fairbairn SM, Page CP, Lees P, et al. Early neutrophil but not eosinophil or platelet recruitment to the lungs of allergic horses following antigen exposure. Clin Exp Allergy 1993; 23:821-828. - PubMed -
 
24.  Broadstone RV, Scott JS, Derksen FJ, et al. Effects of atropine in ponies with recurrent airway obstruction. J Appl Physiol 1988; 65:2720-2725. - PubMed -
 
25.  Olszewski MA, Robinson NE, Zhou FX, et al. Mediators of anaphylaxis but not activated neutrophils augment cholinergic responses of equine small airways. Am J Physiol 1999; 276:L522-29. - PubMed -
 
26.  Olszewski MA, Zhang XY, Robinson NE. Pre- and postjunctional effects of inflammatory mediators in horse airways. Am J Physiol 1999; 277:L327-L333. - PubMed -
 
27.  Robinson NE, Derksen FJ, Berney C, et al. The airway response of horses with recurrent airway obstruction (heaves) to aerosol administration of ipratropium bromide. Equine Vet J 1993; 25:299-303. - PubMed -
 
28.  Gerber V, King M, Schneider DA, et al. Tracheobronchial mucus viscoelasticity during environmental challenge in horses with recurrent airway obstruction. Equine Vet J 2000; 32:411-7. - PubMed -
 
29.  Jefcoat AM, Hotchkiss JA, Harkema JR, et al. Persistent mucin glycoprotein alterations in equine recurrent airway obstruction. Am J Physiol Lung Cell Mol Physiol 2001; 281:L704-L712. - PubMed -
 
30.  Kaup F-J, Drommer W, Deegen E. Ultrastructural findings in horses with chronic obstructive pulmonary disease (COPD) I: alterations of the larger conducting airways. Equine Vet J 1990; 22:343-348. - PubMed -
 
31.  Kaup F-J, Drommer W, Damsch S, et al. Ultrastructural findings in horses with chronic obstructive pulmonary disease (COPD) II: pathomorphological changes of the terminal airways and the alveolar region. Equine Vet J 1990; 22:349-355. - PubMed -
 
32.  Raulo SM, Sorsa TA, Maisi PS. Concentrations of elastinolytic metalloproteinases in respiratory tract secretions of healthy horses and horses with chronic obstructive pulmonary disease. Am J Vet Res 2000; 61:1067-73. - PubMed -
 
33.  Raulo SM, Sorsa T, Tervahartiala T, et al. MMP-9 as a marker of inflammation in tracheal epithelial lining fluid (TELF) and in bronchoalveolar fluid (BALF) of COPD horses. Equine Vet J 2001; 33:128-36. - PubMed -
 
34.  Derksen FJ, Robinson NE, Armstrong PJ, et al. Airway reactivity in ponies with recurrent airway obstruction (heaves). J Appl Physiol 1985; 58:598-604. - PubMed -
 
35.  Klein H-J, Deegen E. Histamine inhalation provocation test: Method to identify nonspecific airway reactivity in equine. Am J Vet Res 1986; 47:1796-1800. - PubMed -
 
36.  Armstrong PJ, Derksen FJ, Robinson NE, et al. Airway responses to aerosolized methacholine and citric acid in ponies with recurrent airway obstruction (heaves). Am Rev Respir Dis 1986; 133:357-361. - PubMed -
 
37.  Derksen FJ, Scott DS, Robinson NE, et al. Intravenous histamine adminstration in ponies with recurrent airway obstruction (heaves). Am J Vet Res 1985; 46:774-777. - PubMed -
 
38.  Fairbairn SM, Lees P, Page CP, et al. Duration of antigen-induced hyperresponsiveness in horses with allergic respiratory disease and possible links with early airway obstruction. J Vet Pharmacol Ther 1993; 16:469-476. - PubMed -
 
39.  Broadstone RV, Scott JS, Derksen FJ, et al. In vitro response of airway smooth muscle from horses with recurrent airway obstruction. Pulm Pharmacol 1991; 4:191-202. - PubMed -
 
40.  Yu M, Wang ZW, Robinson NE, et al. Modulation of bronchial smooth muscle function in horses with heaves. J Appl Physiol 1994; 77:2149-2154. - PubMed -
 
41.  Holcombe SJ, Jackson C, Gerber V, et al. Stabling is associated with airway inflammation in young Arabian horses. Equine Vet J 2001; 33:244-9. - PubMed -
 
42.  Tremblay GM, Ferland C, Lapointe J-M, et al. Effect of stabling on bronchoalveolar cells obtained from normal and COPD horses. Equine Vet J 1993; 25:194-197. - PubMed -
 
43.  Art T, Kirschvink N, Smith N, et al. Indices of oxidative stress in blood and pulmonary epithelium lining fluid in horses suffering from recurrent airway obstruction. Equine Vet J 1999; 31:397-401. - PubMed -
 
44.  Art T, Kirschvink N, Smith N, et al. Cardiorespiratory measurements and indices of oxidative stress in exercising COPD horses. Equine Vet J Suppl 1999; 30:83-7. - PubMed -
 
45.  Bureau F, Delhalle S, Bonizzi G, et al. Mechanisms of persistent NF-?B activity in the bronchi of an animal model of asthma. J. Immunol 2000; 165:5822-5830. - PubMed -
 
46.  Turlej RK, Fievez L, Sandersen CF, et al. Enhanced survival of lung granulocytes in an animal model of asthma: evidence for a role of GM-CSF activated STAT5 signalling pathway. Thorax 2001; 56:696-702. - PubMed -
 
47.  Nyman G, Lindberg R, Weckner D, et al. Pulmonary gas exchange correlated to clinical signs and lung pathology in horses with chronic bronchiolitis. Equine Vet J 1991; 23:253-260. - PubMed -
 
48.  Robinson NE, Olszewski MA, Boehler D, et al. Relationship between clinical signs and lung function in horses with recurrent airway obstruction (heaves) during a bronchodilator trial. Equine Vet J 2000; 32:393-400. - PubMed -
 
49.  Petsche VM, Derksen FJ, Robinson NE. Tidal breathing flow-volume loops in horses with recurrent airway obstruction (heaves). Am J Vet Res 1994; 55:885-891. - PubMed -
 
50.  Breeze RG. Heaves: The problem of disease definition. Vet Clin North Am Large Anim Pract 1979; 1:219-230.
 
51.  Costa LRA, Seahorn TL, Moore RM, et al. Correlation of clinical score, intrapleural pressure, cytologic findings of bronchoalveolar lavage fluid, and the histopathologic lesions of pulmonary tissue with summer pasture-associated obstructive pulmonary disease. Am J Vet Res 2000; 61:167-173. - PubMed -
 
52.  Derksen FJ, Brown CM, Sonea I, et al. Comparison of transtracheal aspirate and bronchoalveolar lavage cytology in 50 horses with chronic lung disease. Equine Vet J 1989; 21:23-26. - PubMed -
 
53.  Robinson NE, Berney C, Olszewski M, et al. Determinants of maximal changes in pleural pressure in horses with heaves. In: Proceedings of the 13th Vet Respir Symp 1994:A11.
 
54.  Willoughby RA, McDonnell WN. Pulmonary function testing in horses. Vet Clin North Am Large An Pract 1979; 1:171-191. - PubMed -
 
55.  Gallivan GJ, Viel L, McDonnell WN. An evaluation of the multiple-breath nitrogen washout as a pulmonary function test in horses. Can J Vet Res 1990; 54:99-105. - PubMed -
 
56.  Herholz C, Busato A, Straub R. [Lung function tests in horses with special reference to ultrasound-spirometry/capnography]. Schweiz Arch Tierheilkd 2000;142: 299-303.
 
57.  Herholz C, Straub R, Busato A. Ultrasound-spirometry and capnography in horses: analysis of measurement reliability. Vet Res Commun 2001; 25:137-47. - PubMed -
 
58.  Votion D, Ghafir Y, Vandenput S, et al. Analysis of scintigraphical lung images before and after treatment of horses suffering from chronic pulmonary disease. Vet Rec 1999; 144:232-236. - PubMed -
 
59.  Derksen FJ, Slocombe RF, Brown CM, et al. Chronic restrictive pulmonary disease in a horse. J Am Vet Med Assoc 1982; 180:887-9.
 
60.  Peroni JF, Horner NT, Robinson NE, et al. Equine thoracoscopy: normal anatomy and surgical technique. Equine Vet J 2001; 33:231-7. - PubMed -
 
61.  Peroni JF, Robinson NE, Stick JA, et al. Pleuropulmonary and cardiovascular consequences of thoracoscopy performed in healthy standing horses. Equine Vet J 2000; 32:280-6. - PubMed -
 
62.  Lowell FC. Observations on heaves: an asthma-like syndrome in the horse. J Allergy 1964; 35:322-330.
 
63.  Jackson CA, Berney C, Jefcoat AM, et al. Environment and prednisone interactions in the treatment of recurrent airway obstruction (heaves). Equine Vet J 2000; 32:432-438. - PubMed -
 
64.  Dixon PM, Railton DI, McGorum BC. Equine pulmonary disease: a case control study of 300 referred cases. Part 2: details of animals and historical and clinical findings. Equine Vet J 1995; 27:422-427. - PubMed -
 
65.  Markham G. Markhams Maister-peece: Containing All Knowledge Belonging to the Smith, Farrier, or Horse-leech. London: W. Wilson, 1656.
 
66.  Vandenput S, Votion D, Duvivier D, et al. Effect of a set stabled environmental control on pulmonary function and airway reactivity of COPD affected horses. Vet J 1998; 155:189-195. - PubMed -
 
67.  Vandenput S, Duvivier DH, Votion D, et al. Environmental control to maintain stabled COPD horses in clinical remission: effects on pulmonary function. Equine Vet J 1998; 30:93-96. - PubMed -
 
68.  Thomson JR, McPherson EA. Effects of environmental control on pulmonary function of horses affected with chronic obstructive pulmonary disease. Equine Vet J 1984; 16:35-38. - PubMed -
 
69.  Gray PR, Derksen FJ, Robinson NE, et al. The role of cyclo-oxygenase products in the acute airway obstruction and airway hyperreactivity of ponies with heaves. Am Rev Respir Dis 1989; 140:154-160. - PubMed -
 
70.  Watson ED, Sweeney CR, Steensma KA. Arachidonate metabolites in bronchoalveolar lavage fluid from horses with and without COPD. Equine Vet J 1992; 24:379-381. - PubMed -
 
71.  Venugopal CS, Moore RM, Holmes EP, et al. Comparative responses of bronchial rings to mediators of airway hyperreactivity in healthy horses and those affected with summer pasture-associated obstructive pulmonary disease. Am J Vet Res 2001; 62:259-63. - PubMed -
 
72.  Barnes PJ. Molecular mechanisms of glucocorticoid action in asthma. Pulm Pharmacol Ther 1997; 10:3-19.
 
73.  Robinson NE, Jackson C, Jefcoat A, et al. Efficacy of three corticosteroids for the treatment of recurrent airway obstruction (heaves). Equine Vet J 2001 (in press).
 
74.  Rush BR, Raub ES, Rhoads WS, et al. Pulmonary function in horses with recurrent airway obstruction after aerosol and parenteral administration of beclomethasone dipropionate and dexamethasone, respectively. Am J Vet Res 1998; 59:1039-1043. - PubMed -
 
75.  Cunningham FE, Rogers S, Fischer JH, et al. The pharmacokinetics of dexamethasone in the thoroughbred racehorse. J Vet Pharmacol Ther 1996; 19:68-71.
 
76.  Jackson CA, Robinson NE, Berney CEA, et al. Prednisone--is it really effective in the treatment of chronic obstructive pulmonary disease? In: Proceedings of the 45th Annual AAEP Convention 1999; 304-305.
 
77.  Robinson NE, Jackson CA, Peroni D, et al. Why is oral prednisone ineffective for treatment of heaves? In: Proceedings of the 46th Annual AAEP Convention 2000; 266-267.
 
78.  LaPointe J-M, Lavoie J-P, Vrins AA. Effects of triamcinolone acetonide on pulmonary function and bronchoalveolar lavage cytologic features in horses with chronic obstructive pulmonary disease. Am J Vet Res 1993; 54:1310-1316. - PubMed -
 
79.  National asthma eduation and prevention program expert panel. Report 2: Guidelines for the diagosis and management of asthma. Washington DC: US Government Printing Office. NIH - NHLBI Publication No. 97-4051, 1997.
 
80.  Proceedings of the ATS workshop on refractory asthma: current understanding, recommendations, and unanswered questions. American Thoracic Society. Am J Respir Crit Care Med 2000; 162:2341-51.
 
81.  Barnes PJ. Current issues for establishing inhaled corticosteroids as the antiinflammatory agents of choice in asthma. J Allergy Clin Immunol 1998; 101:S427-33. - PubMed -
 
82.  Barnes N. Relative safety and efficacy of inhaled corticosteroids. J Allergy Clin Immunol 1998; 101:S460-4. - PubMed -
 
83.  Barnes PJ, Pedersen S, Busse WW. Efficacy and safety of inhaled corticosteroids. New developments. Am J Respir Crit Care Med 1998; 157:S1-53.
 
84.  Tesarowski DB, Viel L, McDonell WN, et al. The rapid and effective administration of a beta 2-agonist to horses with heaves using a compact inhalation device and metered-dose inhalers. Can J Vet Res 1994; 35:170-173. - PubMed -
 
85.  Rush BR, Hoskinson JJ, Davis EG, et al. Pulmonary distribution of aerosolized technetium Tc 99m pentetate after administration of a single dose of aerosolized albuterol sulfate in horses with recurrent airway obstruction. Am J Vet Res 1999; 60:764-769. - PubMed -
 
86.  Ammann VJ, Vrins AA, Lavoie J-P. Effects of inhaled beclomethasone dipropionate on respiratory function in horses with chronic obstructive pulmonary disease (COPD). Equine Vet J 1998; 30:152-157. - PubMed -
 
87.  Rush BR, Flaminio MJ, Matson CJ, et al. Cytologic evaluation of bronchoalveolar lavage fluid in horses with recurrent airway obstruction after aerosol and parenteral administration of beclomethasone dipropionate and dexamethasone, respectively. Am J Vet Res 1998; 59:1033-1038. - PubMed -
 
88.  Rush BR, Raub ES, Thomsen MM, et al. Pulmonary function and adrenal gland suppression with incremental doses of aerosolized beclomethasone dipropionate in horses with recurrent airway obstruction. J Am Vet Med Assoc 2000; 217:359-64. - PubMed -
 
89.  Grebe SK, Feek CM, Durham JA, et al. Inhaled beclomethasone dipropionate suppresses the hypothalamo-pituitary-adrenal axis in a dose dependent manner. Clin Endocrinol (Oxf) 1997; 47:297-304. - PubMed -
 
90.  O'Byrne PM, Pedersen S. Measuring efficacy and safety of different inhaled corticosteroid preparations. J Allergy Clin Immunol 1998; 102:879-86. - PubMed -
 
91.  Sorkness CA. Establishing a therapeutic index for the inhaled corticosteroids: part II. Comparisons of systemic activity and safety among different inhaled corticosteroids. J Allergy Clin Immunol 1998; 102:S52-64. - PubMed -
 
92.  Lipworth BJ. Systemic adverse effects of inhaled corticosteroid therapy: A systematic review and meta-analysis. Arch Int Med 1999; 159:941-55. - PubMed -
 
93.  Viel L, Celly C, Staempfli H, et al. Therapeutic efficacy of inhaled fluticasone propionate in horses with chronic obstructive pulmonary disease. In: Proceedings of the 45th Ann Convention AAEP 1999; 306-307.
 
94.  McKiernan BC, Koritz GD, Scott JS, et al. Plasma theophylline concentration and lung function in ponies with recurrent obstructive lung disease. Equine Vet J 1990; 22:194-197. - PubMed -
 
95.  Pearson EG, Riebold TW. Comparison of bronchodilators in alleviating clinical signs in horses with chronic obstructive pulmonary disease. J Am Vet Med Assoc 1989; 194:1287-91. - PubMed -
 
96.  Murphy JR, McPherson EA, Dixon PM. Chronic obstructive pulmonary disease (COPD): effects of bronchodilator drugs on normal and affected horses. Equine Vet J 1980; 12:10-4. - PubMed -
 
97.  Dixon PM. Pulmonary artery pressure in normal horses and in horses affected with chronic obstructive pulmonary disease. Equine Vet J 1978; 10:195-198. - PubMed -
 
98.  Duvivier DH, Votion D, Vandenput S, et al. Airway response of horses with COPD to dry powder inhalation of ipratropium bromide. Vet J 1997; 154:149-53. - PubMed -
 
99.  Duvivier DH, Bayly WM, Votion D, et al. Effects of inhaled dry powder ipratropium bromide on recovery from exercise of horses with COPD. Equine Vet J 1999; 31:20-4. - PubMed -
 
100.  Erichsen DF, Aviad AD, Schultz RH, et al. Clinical efficacy and safety of clenbuterol HCl when administered to effect in horses with chronic obstructive pulmonary disease. Equine Vet J 1994; 26:331-336.
 
101.  Sasse HH, Hajer R. [Veterinary and clinical experience of the use of a beta2-receptor-stimulating sympathicomimetic agent (NAB 365) in horses with respiratory disease]. Dutch. Tijdschr Diergeneeskd 1977; 102:1233-1238. - PubMed -
 
102.  Turgut K, Sasse HH. Influence of clenbuterol on mucociliary transport in healthy horses and horses with chronic obstructive pulmonary disease. Vet Rec 1989; 125:526-530. - PubMed -
 
103.  Derksen FJ, Olszewski M, Robinson NE, et al. Use of a hand-held, metered-dose aerosol delivery device to administer pirbuterol acetate to horses with `heaves'. Equine Vet J 1996; 28:306-310. - PubMed -
 
104.  Derksen FJ, Olszewski MA, Robinson NE, et al. Aerosolized albuterol sulfate used as a bronchodilator in horses with recurrent airway obstruction. Am J Vet Res 1999; 60:689-693. - PubMed -
 
105.  Lotvall J, Svedmyr N. Salmeterol: an inhaled beta 2-agonist with prolonged duration of action. Lung 1993; 171:249-64. - PubMed -
 
106.  Henrikson SL, Rush BR. Efficacy of salmeterol xinafoate in horses with recurrent airway obstruction. J Am Vet Med Assoc 2001; 218:1961-5. - PubMed -
 
107.  McGorum BC, Dixon PM, Halliwell REW. Quantification of histamine in plasma and pulmonary fluids from horses with chronic obstructive pulmonary disease, before and after "natural (hay and straw) challenges". Vet Immunol Immunopathol 1993; 36:223-237. - PubMed -
 
108.  Tasche MJ, Uijen JH, Bernsen RM, et al. Inhaled disodium cromoglycate (DSCG) as maintenance therapy in children with asthma: a systematic review. Thorax 2000; 55:913-20. - PubMed -
 
109.  Konig P. The effects of cromolyn sodium and nedocromil sodium in early asthma prevention. J Allergy Clin Immunol 2000; 105:S575-81. - PubMed -
 
110.  Hare JE, Viel L, Conlon PD, et al. The effect of sodium cromoglycate on light racehorses with elevated metachronomatic cell numbers on bronchoalveolar lavage and reduced exercise tolerance. J Vet Pharmacol Ther 1994; 17:237-244. - PubMed -
 
111.  Soma LR, Beech J, Gerber NH. Effects of cromolyn in horses with chronic obstructive pulmonary disease. Vet Res Commun 1987; 11:339-351. - PubMed -
 
112.  Thomson JR, McPherson EA. Prophylactic effects of sodium cromoglycate on chronic obstructive pulmonary disease in the horse. Equine Vet J 1981; 13:243-246. - PubMed -
 
113.  Bianco S, Pieroni MG, Refini RM, et al. Protective effect of inhaled furosemide on allergen-induced early and late asthmatic reactions. N Engl J Med 1989; 321:1069-73. - PubMed -
 
114.  Bianco S, Vaghi A, Robuschi M, et al. Prevention of exercise-induced bronchoconstriction by inhaled frusemide. Lancet 1988; 2:252-5. - PubMed -
 
115.  Broadstone RV, Robinson NE, Gray PR, et al. Effects of furosemide on ponies with recurrent airway obstruction. Pulm Pharmacol 1991; 4:203-208. - PubMed -
 
116.  Rubie S, Robinson NE, Stoll M, et al. Flunixin meglumine blocks frusemide-induced bronchodilation in horses with chronic obstructive pulmonary disease. Equine Vet J 1993; 25:138-142. - PubMed -
 
117.  Broadstone RV, Gray PG, Robinson NE, et al. Effects of xylazine on airway function in ponies with recurrent airway obstruction. Am J Vet Res 1992; 53:1813-1817. - PubMed -
 
118.  Yu M, Wang Z, Robinson NE. Prejunctional alpha2-adrenoceptors inhibit acetylcholine release from cholinergic nerves in equine airways. Am J Physiol: Lung Cell Mol Physiol 1993; 265:L565-L570. - PubMed -
 
119.  Aviza GA, Ainsworth DM, Eicker SW, et al. Outcome of horses diagnosed and treated for heaves (recurrent airway obstruction). Equine Vet Educ 2001; 3:318-320.  

 
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